| 姜志超,胡 力,申汉威,汪立刚,杨孔宾.钾离子通道与神经胶质瘤关系的研究进展[J].,2017,17(5):997-1000 |
| 钾离子通道与神经胶质瘤关系的研究进展 |
| Research Progress of The Relationship between Potassium Channels and Glioma |
| 投稿时间：2016-03-28 修订日期：2016-04-23 |
| DOI：10.13241/j.cnki.pmb.2017.05.053 |
| 中文关键词: 钾离子通道 神经胶质瘤 研究进展 |
| 英文关键词: Potassium channels Glioma Research progress |
| 基金项目:国家自然科学基金项目（30600641）；黑龙江省教育厅基金项目（11511209）；黑龙江省政府博士后基金项目（LRB03174） |
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| 中文摘要: |
| 摘要：钾离子通道为组织细胞内分布最广、种类最多的离子通道，在细胞增殖、分化及肿瘤细胞的侵袭转移中起着关键作用。神经胶质瘤是颅内最多发的恶性肿瘤，目前其主要治疗方式为手术加术后放化疗，术后五年生存率较低，寻找其相关发病机制及化疗靶点具有重要意义。目前已有多项研究表明，多种钾离子通道在胶质瘤中呈特异性高表达，且与胶质瘤的增殖、分化有密切关系，一些钾离子通道可作为胶质瘤的诊断和预防因子，有望成为未来胶质瘤化疗的新靶点，研究钾离子通道与神经胶质瘤的关系对胶质瘤的诊断、预防和治疗有重要意义。本文主要对近年来钾离子通道与神经胶质瘤关系研究的新进展进行综述。 |
| 英文摘要: |
| ABSTRACT: Potassium ion channel is the most widely distributed ion channels within the tissue cells, and plays a key role in the cell proliferation, differentiation and invasion and metastasis of tumor cells. Glioma is the multiple intracranial malignant tumor, the pa- tients' postoperative five-year survival rate is low, the research on the pathogenesis of glioma is of great significance. A number of studies have shown that a variety of potassium ion channels were specific highly expressed in glioma, which were closely related to the prolifera- tion, differentiation of glioma, some of the potassium ion channel could be used as a glial diagnosis and prevention factors. Some potas- sium ion channels were expected to be the new therapeutic targets for the chemotherapy of glioma in the future. The study on the rela- tionship between potassium ion channels were of great importance in the diagnosis, prevention and treatment of glioma.This article overviewed the research progress of the relationship between potassium channels and glioma in recent years. |
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