| 周雯娟,程 友,包亚军,武颖异,耿莉莉.过敏性鼻炎患儿淋巴细胞亚群与血清IgE水平变化及意义[J].,2017,17(5):859-861 |
| 过敏性鼻炎患儿淋巴细胞亚群与血清IgE水平变化及意义 |
| Changes of Lymphocyte Subsets and Serum IgE Levels in Children with Allergic Rhinitis and Its Significance |
| 投稿时间：2016-08-15 修订日期：2016-09-12 |
| DOI：10.13241/j.cnki.pmb.2017.05.014 |
| 中文关键词: 过敏性鼻炎 淋巴细胞 IgE 临床意义 |
| 英文关键词: Allergic rhinitis Lymphocyte IgE Clinical significance |
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| 中文摘要: |
| 摘要 目的：研究过敏性鼻炎患儿淋巴细胞亚群与血清免疫球蛋白E (IgE)水平变化及其临床意义，为临床诊疗提供依据。方法：选取2015年6月到2016年6月我院收治的过敏性鼻炎患儿103例为研究组，另选取同期健康体检者103例为对照组，应用流式细胞技术检测CD3+、CD4+、CD19+、CD8+、CD4+CD25+水平，应用酶联免疫吸附法检测白介素-4（IL-4）、白介素-5（IL-5）和干扰素-γ（IFN-γ）水平，应用免疫比浊法检测IgE水平，对比两组淋巴细胞亚群水平、血清中IL-4、IL-5、IFN-γ水平及IgE水平的变化,并分析其相关性。结果：研究组CD3+、CD4+、CD8+、CD4+CD25+显著低于对照组，CD19+显著高于对照组，比较差异具有统计学意义（P＜0.05）；研究组IL-4、IL-5水平显著高于对照组，IFN-γ水平显著低于对照组，比较差异具有统计学意义（P＜0.05）；研究组IgE水平显著高于对照组，比较差异具有统计学意义（P＜0.05）；相关性分析显示：CD19+与IgE水平呈正相关关系（P＜0.05）。结论：淋巴细胞亚群失衡、血清IgE均与过敏性鼻炎有关，在过敏性鼻炎发生和发展中发挥重要作用。 |
| 英文摘要: |
| ABSTRACT Objective: To study the changes of lymphocyte subsets and serum immune globulin E (IgE) levels in children with al- lergic rhinitis and its clinical significance, and to provide the basis for clinical diagnosis and treatment. Methods: 103 children with aller- gic rhinitis treated in our hospital from June 2015 to June 2016 were selected as study group, another 103 cases of healthy physical exam- ination were selected as the control group, the levels of CD3+, CD4+, CD19+, CD8+, CD4+CD25+ were detected by using the technique of the loss of cells, Interleukin-4 (IL-4), Interleukin-5 (IL-5) and interferon -γ (IFN-γ) level were detected by using enzyme-linked im- munosorbent assay, IgE level was detected by immunoturbidimetric assay, the levels of lymphocyte subsets, IL-4, IL-5, IFN-γ and IgE were compared between the two groups, and analyzed their correlation. Results: CD3+, CD4+, CD8+, CD4+CD25+ in the study group were significantly lower than the control group, CD19+ was significantly higher than the control group,the differences were statistically signifi- cant (P<0.05); The levels of IL-4 and IL-5 in the study group were significantly higher than those in the control group, the level of IFN-γ were significantly lower than that of control group, the differences were statistically significant (P<0.05); The level of IgE in the study group were significantly higher than that in the control group, the difference was statistically significant (P<0.05); Correlation analysis showed that: CD19+ and IgE levels were positively correlated (P<0.05). Conclusion: The imbalance of lymphocyte subsets and serum IgE were related to allergic rhinitis,which play an important role in the occurrence and development of allergic rhinitis. |
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