| 郑鹏飞,唐和蔚,李红艳,王恩存,申长清,谢忠琳,冯旭阳.巨噬细胞在动脉粥样硬化形成中的作用[J].,2017,17(4):784-786 |
| 巨噬细胞在动脉粥样硬化形成中的作用 |
| The Role of Macrophages in the Formation of Atherosclerosis |
| 投稿时间：2016-04-07 修订日期：2016-04-30 |
| DOI：10.13241/j.cnki.pmb.2017.04.048 |
| 中文关键词: 巨噬细胞 泡沫细胞 动脉粥样硬化 脂肪分化相关蛋白 |
| 英文关键词: Macrophage Foam cell Atherosclerosis ADRP |
| 基金项目:国家自然科学基金面上项目（31171132） |
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| 摘要点击次数: 452 |
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| 中文摘要: |
| 摘要：巨噬细胞是机体免疫系统的重要一员，具有趋化、吞噬、免疫及分泌等功能。在动脉粥样硬化(atherosclerosis，AS)形成过程中，巨噬细胞受低密度脂蛋白氧化修饰过程中的炎性因子趋化，大量吞噬氧化低密度脂蛋白，变为"泡沫细胞"，进而导致动脉粥样硬化病变，并通过免疫及分泌功能生成肿瘤坏死因子?琢等物质加速病变的进展，其功能变化与动脉粥样硬化形成和发展息息相关。ADRP作为PAT家族蛋白中的一员，因在脂滴形成中的重要作用而受到广泛关注。ADRP是动脉粥样硬化过程中的一个关键分子，不仅在病变中起着提高炎症反应与调节脂质代谢的双重作用，而且通过限制泡沫细胞的形成，而影响了动脉粥样硬化的走向。 |
| 英文摘要: |
| ABSTRACT: Macrophages are important cells of the immune system, which have the chemotaxis, phagocytosis, immune, secretion and other functions. In the process of atherosclerosis, macrophages phagocytose the ox-LDL, which the process of inflammatory cytokines chemotaxis, phagocytosis lot of oxidized LDL and become "foam cells", which leads to atherosclerotic lesions and generate substances such as tumor necrosis factor-?琢 secreted by immune function and accelerate the progress of disease, a member with chemotaxis, phagocytosis, and secretion of immune function, inflammatory cytokines by oxidative modification of LDL occurs during chemotaxis, phagocytosis lot of oxidized low-density lipoprotein, become "foam cells", which led to atherosclerotic lesions, and generate substances such as tumor necrosis factor-?琢 accelerates the progress of disease through immunization and secretory functions which change and atherosclerosis formation and development are closely related. ADRP as the PAT protein, a member of the family, because of the important role in the formation of lipid droplets and attracted widespread attention. ADRP is atherosclerosis, a key molecule in the process, not only in improving inflammatory lesions plays a dual role and regulation of lipid metabolism, but also by limiting the formation of foam cells, which will affect the trend of atherosclerosis. |
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