| 于红梅,王洪梅,陈 颖,王晓伟,狄海伦,李 伟.r-tpa合并甘露醇治疗血管壁病变性脑梗死的临床疗效分析[J].,2017,17(4):750-752 |
| r-tpa合并甘露醇治疗血管壁病变性脑梗死的临床疗效分析 |
| Clinical Effect of r-tpa Combined Mannitol in Treatment of Cerebral Infarction Caused by Vascular Diseases |
| 投稿时间：2016-09-22 修订日期：2016-10-20 |
| DOI：10.13241/j.cnki.pmb.2017.04.039 |
| 中文关键词: r-tpa 甘露醇 血管病变性脑梗死 临床疗效 |
| 英文关键词: r-tpa Mannitol Cerebral infarction caused by vascular diseases Clinical effect |
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| 中文摘要: |
| 摘要 目的：观察r-tpa合并甘露醇治疗血管壁病变性脑梗死临床疗效。方法：将临床发病6 h以内的急性脑梗死患者随机分为治疗组与对照组，每组60例，治疗组用r-tpa合并甘露醇静脉滴注，对照组用川芎嗪注射液静脉滴注，对治疗组和对照组连续使用15天观察对照组和治疗组的临床疗效及神经功能恢复情况。结果：采用r-tpa合并甘露醇静脉滴注和川芎嗪静脉注射液疗效比较，治疗组总有效率93.33 %，明显优于常规治疗组78.33 %，两组差异有统计学意义（P＜0.05）。两组患者治疗后CSS评分均显著低于治疗前，且治疗组明显低于对照组 (P＜0.05)；两组患者治疗后ADL评分均显著高于治疗前，且治疗组明显高于对照组 (P<0.05)。结论：r-tpa合并甘露醇治疗血管壁病变性脑梗死临床疗效显著，且对6个小时内没有出血倾向的血管病变性脑梗死安全实用，患者后期恢复效果良好。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical effect of r-tpa combined mannitol in treatment of cerebral infarction caused by vascular diseases. Methods: The patients with acute cerebral infarction (ACI) within 6 hours were randomly divided into treatment group and control group with 60 cases in each group. The patients in treatment group accepted r-tpa combined mannitol, and the patients in control group accepted ligustrazine injection. The clinical efficacy and recovery of neurological function were measured after 15 days treatment. Results: The clinical effect of treatment group was 93.33 %, which was obviously higher than 78.33 % of control group with statistically significance (P<0.05). The CSS scores of two groups after treatment were obviously lower than before, and the treatment group was much lower than control group (P<0.05). The ADL scores of two groups after treatment were obviously higher than before, and the treatment group was much higher than control group (P<0.05). Conclusion: Using r-tpa combined mannitol has good effect in treatment of cerebral infarction caused by vascular diseases, which is safe and good at symptom improvement of later stage. |
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