| 王子宽,杨竞肖,白宝宝,金葵花,郭晓兰.参麦注射液联合不同类型他汀类药物治疗不稳定型心绞痛的近期疗效比较[J].,2017,17(4):664-667 |
| 参麦注射液联合不同类型他汀类药物治疗不稳定型心绞痛的近期疗效比较 |
| Short-term Effects of Shen Mai Injection Combined with Different Types of Statins in the Treatment of Unstable Angina Pectoris |
| 投稿时间：2016-08-12 修订日期：2016-08-29 |
| DOI：10.13241/j.cnki.pmb.2017.04.016 |
| 中文关键词: 冠心病 不稳定型心绞痛 参麦注射液 他汀类药物 |
| 英文关键词: Coronary heart disease Unstable angina Shen Mai injection Statins |
| 基金项目:陕西省卫生厅科研基金项目(110544) |
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| 中文摘要: |
| 摘要 目的：探究参麦注射液联合不同类型他汀类药物治疗不稳定型心绞痛的近期疗效。方法：收集本院收治的不稳定型心绞痛患者37例，随机分成实验组与对照组。对照组18例予参麦注射液联合普伐他汀治疗；实验组19例予参麦注射液联合阿托伐他汀治疗。比较两组治疗前后血脂水平的变化及临床疗效。结果：治疗后，两组总胆固醇(TC)、低密度脂蛋白(LDL-C)水平均较治疗前显著下降(P<0.05)，心绞痛发作次数及时间均明显减少或缩短(P<0.05)；与对照组相比，实验组治疗后的TC、LDL-C水平均较低(P<0.05)；不良反应发生率(15.8%)低于对照组(27.8%)(P<0.05)。结论：参麦注射液联合不同类型他汀类药物治疗不稳定型心绞痛的近期疗效相当，但阿托伐他汀治疗可更有效降低患者的血脂水平，安全性更高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the short-term effects of Shen Mai Injection combined with different types of statins in the treatment of unstable angina pectoris. Methods: 37 cases with unstable angina pectoris were selected and randomly divided into the control group and the experimental group. 18 cases in the control group were treated by Shenmai injection combined with pravastatin and 19 cases in the experimental group were treated by Shen Mai injection combined with atorvastatin. The changes of blood lipid level and clinical therapeutic after treatment were compared between two groups. Results: After treatment, the total cholesterol (TC) and low density lipoprotein (LDL-C) levels in both groups were significantly decreased(P<0.05), the frequency and duration of angina attack were significantly reduced or shortened(P<0.05). Compared with the control group, the TC and LDL-C levels were lower in the experimental group after treatment(P<0.05), the incidence of adverse reactions (15.8%) was lower than that of the control group (27.8%)(P<0.05). Conclusion: The short-term effects of shenmai injection combined with atorvastatin was equal to pravastatin in the treatment of unstable angina pectoris, but atorvastatin could reduce the blood lipid level more effectively and was more safe. |
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