| 米洁 孟繁森 孙全贵 海春旭 王欣.肝细胞核因子的调控作用研究新进展[J].,2017,17(3):598-600 |
| 肝细胞核因子的调控作用研究新进展 |
| Novel Progress in the Regulation and Biological Role of Hepatocyte Nuclear Factors |
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| DOI： |
| 中文关键词: 肝细胞核因子 调控作用 进展 |
| 英文关键词: Hepatocyte nuclear factors Regulation Progress |
| 基金项目:国家自然科学基金青年科学基金项目（31400724）；陕西省自然科学基金青年科学基金项目（2014JQ4135） |
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| 中文摘要: |
| 肝细胞核因子（HNF，Hepatocyte nuclear factor）是调节肝脏基因特异性表达的一类转录因子，主要包括HNF1、HNF3、HNF4
和HNF6 等，这些转录因子相互作用构成复杂的调控网络。HNF 在人体多个重要组织器官如肝、胰、肠、肾等都有不同程度的表
达。研究发现，在多种疾病的患者体内，存在着编码这些因子基因的突变，提示HNF 与维持及调节人体正常生理功能密不可分。
本文旨在对HNF 的研究进展作以系统性综述，为研究HNF相关疾病的发生机制并进行有效的干预提供新思路。 |
| 英文摘要: |
| Hepatocyte nuclear factors (HNFs) is a group of transcription factors required for regulating the expression of several
liver genes, including HNF1, HNF3, HNF4 and HNF6. These factors constitute a complex regulation network. They express in some important
human organs, such as liver, pancreas, intestines and kidney. Associating patients always have the mutation of the genes encoding
these factors. The facts indicate that HNFs are necessary for keeping and regulating the human normal physiological function. The present
review aimed to summarize the novel progress in the biological role of HNFs, and provide new insights into the mechanism and effective
intervention of HNFs-related diseases. |
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