| 刘阳 吴艳 喻荷淋 朱晓荣 蒋莉 陈敏.阿伦膦酸钠与阿法骨化醇联合治疗妇女绝经后骨质疏松症的疗效[J].,2017,17(3):532-535 |
| 阿伦膦酸钠与阿法骨化醇联合治疗妇女绝经后骨质疏松症的疗效 |
| Effect of Alendronate Combined with Alpha Ossification in the Treatment ofPostmenopausal Osteoporosis |
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| DOI： |
| 中文关键词: 阿伦膦酸钠 阿法骨化醇 骨质疏松症 |
| 英文关键词: Alendronate Alpha ossification Postmenopausal osteoporosis |
| 基金项目:四川省自然科学基金项目(H2013505067) |
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| 中文摘要: |
| 目的：探讨妇女绝经后骨质疏松症（PMO）应用阿伦膦酸钠（ALN）与阿法骨化醇联合治疗的临床效果。方法：选取我院门诊
2013 年1月~2015年3 月收治的98 例PMO 患者，按照数字随机表法均分为两组。对照组：在常规钙剂基础上，给予阿法骨化醇
治疗；观察组：在对照组基础上，给予ALN治疗。记录比较两组治疗前后Ward三角区、股骨颈及腰椎L2~L4 骨密度（BMD）水平，
治疗前后翻身、前屈后伸及自发性腰背痛视觉模拟评分法（VAS）评分，治疗前后血清骨钙素(BGP)、骨碱性磷酸酶(BALP)、Ⅰ型胶
原C 端肽(CTX)及抗酒石酸酸性磷酸酶5b（TRACP-5b）水平，用药期间不良反应。结果：观察组治疗后Ward 三角区、股骨颈及腰
椎L2~L4 BMD水平与治疗前比较，均明显改善（P<0.05），且观察组改善程度更加明显（P<0.05）；观察组治疗后翻身、前屈后伸及
自发性腰背痛VAS 评分与治疗前比较，均显著降低（P<0.01），且观察组改善程度更为显著（P<0.01）；观察组治疗后血清BGP、
BALP、CTX 及TRACP-5b 水平与治疗前比较，均显著下降（P<0.01），且观察组改善幅度更为显著（P<0.01）。结论：妇女PMO 应用
ALN 与阿法骨化醇联合治疗更能显著提高BMD 水平，缓解患者疼痛症状，改善骨代谢指标，疗效切实，安全可靠，具有较高临床
参考价值。 |
| 英文摘要: |
| Objective:To investigate the clinical effect of alendronate (ALN) combined with alpha ossification in the treatment of
in postmenopausal osteoporosis(PMO).Methods:98 cases of PMO patients treated in the outpatient department in our hospital from January
2013 to March 2015 were selected and divided into two groups with the method of random number table. The control group, on the
basis of conventional calcium, was given the treatment of alcohol; the observation group, on the basis of the control group, was given
ALN treatment. The ward's triangle, femoral neck and lumbar spine L2~L4 bone mineral density (BMD) level, turn, flexion and spontaneous
low back pain visual simulation score(VAS), serum bone gla protein(BGP), bone alkaline phosphatase(BALP), type I collagen C
telopeptide(CTX) and tartrate resistant acid phosphatase 5b(TRACP-5b) level before and after the treatment, and adverse reactions during
medication were recorded and compared between the two groups.Results:In the observation group after the treatment, ward triangle
area, the femoral neck and lumbar BMD L2~L4 level compared with those before the treatment, significantly improved (P<0.05), and the
improvement degree of the observation group was more obvious (P<0.05); as for the patients in the observation group, flexion extension,
spontaneous and turning back pain VAS scores compared with those before the treatment significantly decreased (P<0.01), and the improvement
degree of the observation group was more significant (P<0.01); after the treatment, the serumlevels of BGP, BALP, CTX and
TRACP-5b in the observation group significantly decreased compared with those before treatment(P<0.01), and the improvement degree
of the observation group was more significant (P<0.01).Conclusion:ALN combined with alpha ossification in the treatment of the treatment
of PMO can significantly improve the level of BMD, relieve patients' pain symptoms and improve bone metabolism indicators, effectively,
safely and reliably, with a high clinical reference value. |
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