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目的：探讨血清尿酸（UA）水平对急性脑梗死患者颈动脉粥样硬化斑块的影响。方法：回顾性分析2011 年6 月至2016 年1 月我院收治的251 例急性脑梗死患者的临床资料，根据有无颈动脉粥样硬化斑块分为伴颈动脉粥样硬化斑块组（观察组）176 例和无颈动脉粥样硬化斑块组（对照组）75 例，观察组根据颈动脉粥样硬化程度分为斑块形成组（113 例）、内中膜增厚组（63 例），根据颈动脉斑块稳定程度分为不稳定组（106 例）、稳定组（70 例），比较各组血清UA 水平，根据UA 水平不同分为高UA 组（134 例）和正常UA 组（117 例），进行颈动脉斑块发生情况比较。结果：观察组的血清UA 水平显著高于对照组，差异有统计学意义（P<0.05）。①斑块形成组和内中膜增厚组血清UA 水平显著高于对照组（P<0.05），而斑块形成组和内中膜增厚组血清UA水平比较，差异无统计学意义（P>0.05）；② 不稳定组血清UA 水平显著高于对照组和稳定组（P<0.05），而稳定组和对照组血清UA 水平比较，差异无统计学意义（P>0.05）；③正常UA组和高UA 组颈动脉斑块的发生情况比较，差异无统计学意义（P>0.05）。结论：血清UA水平可以作为表征急性脑梗死患者伴随出现颈动脉粥样硬化斑块的生物学指标之一，此外，血清UA的水平在颈动脉粥样硬化斑块形成者和不稳定者表达更高，但血清UA水平与颈动脉斑块形成无明显联系。

英文摘要:

Objective:To investigate the influence of serum uric acid (UA) level on carotid atherosclerotic plaque of patient with acute cerebral infarction.Methods:The clinical data of 251 patients with acute cerebral infarction who were treated in our hospital from June 2011 to January 2016 were analyzed retrospectively, they were divided into carotid atherosclerotic plaque group (observation group) with 176 patients and no carotid atherosclerotic plaque group (control group) with 75 patients, according to with or without carotid atherosclerotic plaque. The observation group was divided into plaque formation group (113 cases) and intima-media thickening group (63 cases) according to degree of carotid atherosclerosis, and which was divided into unstable group (106 cases) and stable group (70 cases) according to the stability of carotid plaque. The level of serumUA was compared in each group. All the patients were divided into high UA group (134 cases) and normal UA group (117 cases) according to the level of UA,then compared their occurrence of carotid plaque.Results:The level of serum UA in observation group was significantly higher than that in the control group, the difference was statistically significant (P<0.05). ① The level of serum UA in plaque formation group and intima-media thickening group was significantly higher than that in the control group, the difference was statistically significant (P<0.05), while the level of serum UA was compared between plaque formation group and intima-media thickening group, the difference was not statistically significant(P>0.05). ② The level of serumUA in unstable group was significantly higher than that in the table group and control group (P<0.05), while the level of serum UA was compared between the table group and the control group, the difference was not statistically significant(P>0.05). ③The occurrence of carotid plaques was compared between the high UA group and the normal UA group, the difference was not statistically significant (P>0.05).Conclusion:The level of serumUA can be used as one of the biological indicator of carotid atherosclerotic plaque in patients with acute cerebral infarction. In addition,the levels of serum UA are higher in patients with carotid atherosclerotic plaque formation and instability, but there is no significant correlation between the level of UA and carotid atherosclerotic plaque.

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