| 周燕萍 史珍英 徐卓明 李志浩 黄继红 周春霞 蔡及明△.乌司他丁对体外循环法洛四联症患儿围心脏手术期循环和呼吸功能的影响[J].,2017,17(2):269-271 |
| 乌司他丁对体外循环法洛四联症患儿围心脏手术期循环和呼吸功能的影响 |
| Effects of Ulinastatin on Circulatory and Respiratory Function ofCardiopulmonary Bypass Children with Tetralogy of Fallot duringPerioperative Cardiac Surgery |
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| DOI： |
| 中文关键词: 乌司他丁 法洛四联症 婴幼儿 |
| 英文关键词: Ulinastatin Tetralogy of Fallot Infants |
| 基金项目:天普研究基金资助项目(01201027 ) |
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| 中文摘要: |
| 目的：探讨乌司他丁对体外循环法洛四联症患儿围心脏手术期循环和呼吸功能的影响。方法：选取我院于收治的60 例法洛
四联症婴幼儿参与研究，并将其随机分为对照组和试验组两组，每组患儿30 例。其中试验组患儿在体外循环前以及患儿进行手
术后的三天内每天均给予10000U/kg 乌司他丁，而对照组患儿则在相应的时间点给予等量的生理盐水。分析比较两组患儿的体
外循环时间、心脏停搏时间、手术时间、在监护室治疗的时间以及患儿术后住院时间和患儿肺部感染发生例数等临床病理情况。
结果：所有入选患儿均痊愈出院，在两组患儿的手术操作情况和治疗效果对比中，对照组患儿的手术时间、体外循环时间和心脏
停搏时间均显著低于试验组患儿，但重症监护时间及术后住院时间则高于试验组患儿；在两组患儿治疗后的循环功能指标比较
中，试验组患儿超滤后CVP 和血管活性药物均低于对照组患儿而超滤后MAP 则显著高于对照组患儿；在两组患儿治疗后的呼
吸功能指标的比较中，试验组患儿的动脉血氧分压明显高于对照组患儿以及试验组患儿的术后机械通气时间和肺部感染例数均
低于对照组患儿，两组患儿的数据比较差异除手术时间、体外循环时间和心脏停搏时间外均具有统计学意义（均P＜0.05）。结论：乌
司他丁对体外循环法洛四联症患儿围心脏手术期的循环和呼吸功能具有较好的保护作用，值得在临床上加以广泛推广和运用。 |
| 英文摘要: |
| Objective:To investigate the effects of ulinastatin on circulatory and respiratory function of children with tetralogy of
Fallot in the perioperative period of cardiopulmonary bypass cardiac surgery.Methods:A total of 60 cases of tetralogy of Fallot infants
and young children from our hospital were included in the study, and were randomly divided into control group and experimental group,
with 30 cases in each group. The children in the experimental group were given 10000 U/kg Ulinastatin per day before CPB and within
three days after surgery, while those in control group were given equal volume of normal saline at the corresponding time. Analyze and
compare the clinical pathology indicators such as cardiopulmonary bypass time, time of cardiac arrest, operation time, ICU treatment
time, postoperative hospitalization time and cases with pulmonary infection between the two groups.Results:All enrolled patients were
cured and discharged. Patients in control group had significantly shorter surgery time, cardiopulmonary bypass time and cardiac arrest
time than children in the experimental group, but longer intensive care time and postoperative hospitalization time than those in the
experimental group. As for the circulatory function indexes after treatment, the levels of CVP and vasoactive drugs after ultrafiltration
were lower in the experimental group than children in the control group, while the mean arterial pressure (MAP) after ultrafiltration was
significantly higher than that of patients in the control group. In comparison of the respiratory function index, the arterial partial pressure
of oxygen in the experimental group was significantly higher than in the control group. Patients in experimental group also had less
postoperative mechanical ventilation time than those in the control group. There were less pulmonary infection cases in the experimental
group, too. Differences between the two groups had statistical significance except the data of operation time, cardiopulmonary bypass
time and cardiac arrest time (all P<0.05).Conclusion:Ulinastatin had good protective effect on the circulatory and respiratory function of
cardiopulmonary bypass children with tetralogy of Fallot during cardiac surgery. It is deserved to be widely popularized and applied in
clinic. |
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