| 张薇薇,钟晶敏,李 晶,黄三钱,刘志红,曾 亮.N-myc下游调节基因1在乳腺癌中表达的临床病理意义[J].,2017,17(1):137-140 |
| N-myc下游调节基因1在乳腺癌中表达的临床病理意义 |
| Clinicopathological Study on the Expression of N-myc Downstream-regulated Gene 1 in Breast Cancer |
| 投稿时间：2016-04-14 修订日期：2016-05-10 |
| DOI：10.13241/j.cnki.pmb.2017.01.035 |
| 中文关键词: N-myc下游调节基因1 乳腺癌 临床病理 |
| 英文关键词: N-myc downstream-regulated gene 1 Breast cancer Clinicopathology |
| 基金项目:湖南省科学技术厅科技计划专项项目（2014FJ6090） |
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| 中文摘要: |
| 摘要 目的：探讨N-myc下游调节基因1（N-myc downstream-regulated gene 1，NDRG1）在乳腺癌中表达。方法：收集乳腺癌病例及相应的临床资料包括随访资料，应用免疫组织化学技术检测良性病变(BBD)47例，无淋巴结转移乳腺癌（NMBC)83例，有淋巴结转移乳腺癌（MBC)107例及配对淋巴结转移灶（PLNM)107例中NDRG1的表达，分析NDRG1表达与乳腺癌临床病理指标间（患者年龄、肿块大小、临床分期、组织学类型和分级、淋巴结转移、雌孕激素受体和c-erbB2水平、绝经史）及生存状态的关系。结果：通过免疫组化技术检测乳腺癌中NDRG1的表达，结果显示阳性表达率分别为BBD（95.7 %，45/47），NMBC（96.4 %，80/83），MBC（98.1 %，105/107），PMLN（90.7 %，97/107），MBC组织中NDRG1阳性表达率显著高于PMLN中阳性表达率（P =0.021）。NDRG1与组织学分级相关（P =0.041)，即分化越差的癌表达NDRG1越强。NDRG1的表达状态与乳腺癌患者的生存预后无显著性相关（P=0.196）。结论：NDRG1表达与乳腺癌淋巴结转移和分化有一定关系。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinicopathological significance of N-myc downstream-regulated gene 1(NDRG1) ex- pression in breast cancer. Methods: The clinical data of breast cancer cases and relevant clinical data were collected. The expression of NDRG1 a was detected by immunohistochemical technique in breast lesion tissues including 47 Benign lesions (BBD) cases, 83 breast cancer without lymph node metastasis (NMBC) cases, 107 breast cancer (MBC) with lymph node metastasis cases and 107 matched lymph node metastasis (PLNM). The relationship between NDRG1 expression and clinical pathological parameters of breast cancer (age, tumor size, clinical stage, histological type and grade, lymph node metastasis, estrogen and progesterone receptor, c-erbB2 level, menopause history) was analyzed. Results: The positive expression rate was 95.7 %(45/47) in BBD, 96.4 %(80/83) in NMBC, 98.1 %(105/107) in MBC, 90.7 %(97/107) in PMLN. The positive expression rate of NDRG1 in MBC tissue was significantly higher than that in PMLN（P=0.021). NDRG1 expression was closely associated with histological grading (P=0.041), and the worse the cancer differentia- tion, the stronger the expression of NDRG1. There was no significant correlation between the expression status of NDRG1 and the prog- nosis of breast cancer patients（P=0.196）. Conclusion: The expression of NDRG1 is related to lymph node metastasis and differentiation of breast cancer. |
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