| 刘小野,董 浩,荆瀛黎,金 岚,王 今,吴国聪,张忠涛.结直肠癌患者血清基质金属蛋白酶水平及其临床意义[J].,2017,17(1):48-50 |
| 结直肠癌患者血清基质金属蛋白酶水平及其临床意义 |
| The Serum Levels of Matrix Metalloproteinases in Patients with Colorectal Cancer and Their Significances |
| 投稿时间：2016-04-23 修订日期：2016-05-18 |
| DOI：10.13241/j.cnki.pmb.2017.01.011 |
| 中文关键词: 结直肠癌 基质金属蛋白酶 悬浮芯片技术 |
| 英文关键词: Colorectal cancer Matrix metalloproteinases Bio-Plex Multiplex System |
| 基金项目:北京脑重大疾病研究院科研促进项目(PXM2014_014226_000016)；神经损伤与康复北京市重点实验室2015年度科技创新基地培育与发展专项项目(Z151100001615055)；中央级公益性科研院所基本科研业务费专项资金项目(2015CZ-12) |
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| 中文摘要: |
| 摘要 目的：探讨结直肠癌患者血清基质金属蛋白酶水平及其临床意义。方法：采用Bio-plex200悬浮芯片系统检测33例结直肠癌患者(其中13例为结直肠癌转移患者，20例为结直肠癌非转移组)和30例正常对照组血清中基质金属蛋白酶(MMP)-1、2、3、7、8、9、10、12、13的浓度。结果：与正常对照组相比，结直肠癌患者血清MMP-2、MMP-7、MMP-8、MMP-9、MMP-10、MMP-13的浓度显著上调(P<0.05)，而MMP-1、MMP-3、MMP-12的浓度并无显著性差异(P>0.05)；与结直肠癌非转移组患者相比，结直肠癌转移组患者血清MMP-2和MMP-7的浓度显著升高(MMP-2：P=0.029；MMP-7：P=0.002)。结论：基质金属蛋白酶可能在结直肠癌的发生、发展过程中起重要作用；MMP-2和MMP-7可能成为结直肠癌发生和转移的预测和评估指标。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the serum levels of matrix metalloproteinases in patients with colorectal cancer and their signifi- cances. Methods: 33 colorectal cancer (CRC) patients and 30 healthy subjects were enrolled in this study. The serum levels of MMPs ((MMP)-1, 2, 3, 7, 8, 9, 10, 12, 13) were measured using Bio-plex Multiplex System. Results: Compared with the serum of cases with normal controls, the concentrations of MMP-2, MMP-7, MMP-8, MMP-9, MMP-10 and MMP-13 in serum of cases with colorectal cancer were significantly up-regulated(P<0.05), while the concentrations of MMP-1, MMP-3, MMP-12 showed no significance(P>0.05). Compared with the serum of colorectal cancer patients without metastasis, the concentrations of MMP-2 and MMP-7 in serum of colorec- tal cancer with metastasis were significantly up-regulated (MMP-2: P=0.029; MMP-7: P=0.002). Conclusion: MMPs might play an im- portant role in the development and occurrence of colorectal cancer, MMP-2 and MMP-7 might be used as indicators of predicting and evaluating the occurrence and metastasis of colorectal cancer. |
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