| 王剑 王文第 蔺如 白岩 何文华 王燕侠 刘青△.高危型HPV检测在宫颈ASCUS分流及随访中的应用[J].,2016,16(33):6509-6511 |
| 高危型HPV检测在宫颈ASCUS分流及随访中的应用 |
| Application of High-risk HPV Testing in Shunt Management and Follow-upof Cervical ASCUS |
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| DOI： |
| 中文关键词: 人乳头状瘤病毒 高危型 宫颈非典型鳞状上皮细胞 |
| 英文关键词: Human papilloma virus Risk type Cervical atypical squamous cells |
| 基金项目:甘肃省科技厅国际科技合作专项(1504WKCA060) |
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| 中文摘要: |
| 目的：分析高危型人乳头瘤病毒（HPV）检测对宫颈非典型鳞状上皮细胞（ASCUS）患者分流管理的作用，提高分流管理合理
性。方法：对200 例经液基薄层细胞学(TCT)检查确诊为ASCUS 患者采用荧光定量聚合酶链反应技术(FQPCR)检测HPV分型，
并进行病理活检。观察高位型HPV 阳性率及分型及其与宫颈病变的关系。结果：200 例患者中有101 例检出高危型HPV阳性，阳
性率为50.50%；病理活检确诊正常或炎症、宫颈上皮内瘤变（CIN）I级、CINII~III 级、鳞状细胞癌各有114 例、32例、51 例、3 例，分
别占57.00%、16.00%、25.50%、1.50%，高危型HPV 阳性率分别为18.42%、87.50%、96.08%、100.00%，≥ CINII级病变患者高危型
HPV 阳性率高于 |
| 英文摘要: |
| Objective:To analyze the value of HPV testing applied in shunt management and follow-up of cervical atypical
squamous cells patients (ASCUS), in order to improve rationality of shunt management.Methods:A total of 200 patients diagnosed as
ASCUS by TCT had their HPV type detected by fluorescence quantitative polymerase chain reaction (FQPCR) and biopsy. Analyze the
relationship of the high risk HPV positive rate and type with the cervical lesions.Results:Among the 200 patients, 101 cases were
detected out of high-risk HPV, with positive rate of 50.50%. According to the pathology biopsy results, there were 114 cases of NLM, 32
cases of CIN I, 51 cases of CIN II ~ III, 3 cases of squamous cell carcinoma (SCC), accounting for 57.00%, 16.00%, 25.50%and 1.50%
respectively. Their high-risk HPV-positive rates were 18.42%, 87.50%, 96.08%and 100.00%respectively. Patients of ≥ CIN II high-risk
had higher HPV positive rate than those of < CIN II, with significant differences (P<0.05).Conclusion:High-risk HPV testing can
provide a reliable basis for reasonable shunt of ASCUS. |
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