| 陈相 陈秋芳 蒋艾豆 沈惠亮 龚国清△.基于血小板糖蛋白受体GPIbα的血栓形成研究进展[J].,2016,16(32):6394-6396 |
| 基于血小板糖蛋白受体GPIbα的血栓形成研究进展 |
| The Research Progress on Thrombosis of Platelet GPIbα* |
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| DOI： |
| 中文关键词: 血栓 GPIbα 血小板 |
| 英文关键词: Thrombus GPIbα Platelet |
| 基金项目:国家自然科学基金项目（81373415） |
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| 中文摘要: |
| 血栓的形成严重影响了人类的健康，迄今为止尚未明确其形成机制。研究发现，血小板上的一种受体GPIbα，在血栓的形成
中发挥重要作用。GPIbα通过与凝血酶和VWF的结合而激活血小板，是促成血栓的形成的主要途径；结合位点位于GPIb琢的
265-288 残基区域，并受到其他区域的调节。其他途径，如GPIbα的膜外功能区脱落形成sGPIb，同样也会对血栓的形成造成影响。
体内多种因素的影响，如PARs、ADAM-17 和14-3-3ζ 等，会对GPIbα的生理功能造成影响，并最终影响了血栓的形成。本文主
要对目前基于GPIbα受体的血栓形成研究成果，对GPIbα的结构、功能和介导血栓形成的机制作一综述，期望对血栓形成和治疗
的进一步研究起到一定的帮助。 |
| 英文摘要: |
| The thrombosis disease is a serious hazard to human health, but the mechanism of it was not clear. It has been
reported that GPIbα, one of the receptors on platelet, is crucial in thrombosis disease. Platelet activation is of critical importance for the
mechanism of thrombosis disease, mediated by the binding of thrombin and VWF to GPIbα. The binding sites locate on the 265-288
residues of GPIbαand the binding is regulated by other regions of GPIbα. In addition, other approaches, such as sGPIb caused by
ectodomain shedding of GPIbα, also lead to thrombosis disease. The function of GPIbαis affected by some factors like PARs,
ADAM-17, 14-3-3ζ and so on. Recent researches of the construction, function and mechanism of GPIbαwere reviewed in this article.
The purpose of this review is to provide new ways to explore the mechanismand treatment of thrombosis disease. |
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