| 潘改燕 潘艳 张鹏 肖海娟 岳敏.益气活血解毒中药联合奥沙利铂对晚期肝癌AFP, VEGF的影响[J].,2016,16(31):6124-6127 |
| 益气活血解毒中药联合奥沙利铂对晚期肝癌AFP, VEGF的影响 |
| Effects of Yiqi Huoxue Jiedu Method and Oxaliplatin on SerumLevels ofAFP and VEGF and Clinical Efficacy for Patients with Advanced LiverCancer |
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| DOI： |
| 中文关键词: 肝癌晚期 益气活血解毒法 奥沙利铂 VEGF HIF-1alpha |
| 英文关键词: Advanced Liver cancer Advanced Yiqi huoxue jiedu method Oxaliplatin Vascular endothelial growth factor (VEGF) HIF-1alpha |
| 基金项目:陕西省自然科学基金项目(2004C2-28) |
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| 中文摘要: |
| 目的：探讨益气活血解毒中药联合奥沙利铂治疗晚期肝癌的临床疗效。方法：选择在我院接受治疗的晚期肝癌患者56 例，
随机分为对照组和观察组，每组28 例。对照组患者采用奥沙利铂栓塞治疗，观察组患者采用奥沙利铂栓塞联合益气活血解毒中
药治疗。观察并比较两组患者治疗前后血清缺氧诱导因子-1alpha(HIF-1alpha)、甲胎蛋白（AFP）、脯氨酸羟化酶2（PHD2）、血管内皮生长
因子（VEGF）水平的变化情况以及临床总有效率。结果：与治疗前相比，两组治疗后患者血清AFP，VEGF，HIF-1琢及PHD2 水平均
降低，差异具有统计学意义(P<0.05)；与对照组比较，观察组患者治疗后血清AFP，VEGF，HIF-1alpha及PHD2 水平较低，差异具有统
计学意义(P<0.05)；观察组临床总有效率(92.59 %)高于对照组(71.43 %)，差异具有统计学意义(P<0.05)。结论：益气活血解毒中药联
合奥沙利铂能够降低肝癌晚期患者血清AFP，VEGF，HIF-1alpha及PHD2 水平，提高临床疗效。 |
| 英文摘要: |
| Objective:To investigate the effects of yiqi huoxue jiedu method combined with oxaliplatin on the serum levels of
AFP and VEGF and the clinical efficacy for patients with advanced liver cancer.Methods:56 patients with advanced liver cancer were
collected and randomly divided into control group and experiment group with 28 cases in each group. The patients in the control group
were treated with oxaliplatin, while the patients in the experiment group were treated with yiqi huoxue jiedu parenteral besides of the
control group. Then the serum levels of HIF - 1alpha, AFP, PHD2 and VEGF and clinical effective rate in the two groups were observed and
compared before and after the treatment.Results:Compared with before treatment, after treatment the level of AFP, VEGF, PHD2 and
HIF-1alpha of patients was decreased (P<0.05); compared with control group, the level of AFP, VEGF, HIF - 1 alpha and PHD2 of the experiment
group were lower (P<0.05), and the clinical total effective rate was higher in the experiment group with statistical significance (P<0.
05).Conclusion:Yiqi huoxue jiedu method combined with oxaliplatin in the treatment of patients with advanced liver cancer can effectively
improve the clinical efficacy, and its mechanismmay be related with down-regulation of VEGF, PHD2 and HIF - 1alpha levels |
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