| 吕红博 何占鳌 王洪江 孙伟 庞作良.microRNA-21 表达水平对新疆地区食管癌患者早期诊断及预后评估的临床价值[J].,2016,16(31):6055-6059 |
| microRNA-21 表达水平对新疆地区食管癌患者早期诊断及预后评估的临床价值 |
| Clinical Value of MicroRNA-21 Expression in Early Diagnosis and Prognosisof Esophageal Cancer in Xinjiang |
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| DOI： |
| 中文关键词: microRNA-21 食管癌 新疆地区 |
| 英文关键词: MicroRNA-21 Esophageal cancer Xinjiang area |
| 基金项目:新疆维吾尔自治区科技厅科技支疆项目（201491175） |
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| 中文摘要: |
| 目的：探讨microRNA-21表达水平对新疆地区食管癌早期诊断及预后评估的临床价值。方法：收集我院收治的100 例食管
癌患者，其中哈萨克族患者50 例，汉族患者50 例，采用RT-PCR 以及RT-qPCR 的方法对患者血清microRNA-21表达水平进行
检测并比较。结果：食管癌患者癌组织中microRNA-21 表达水平均高于癌旁组织，差异具有统计学意义（P<0.05）；有淋巴结转移、
IIB+III 期、低分化癌组织中的miRNA-21 相对表达量高于无淋巴结转移、I+IIA 期以及高分化癌组织患者，差异具有统计学意义
（P<0.05）；miRNA-21 在不同民族、性别、年龄分组中表达无明显差异（P>0.05）。结论：microRNA-21 表达水平对新疆地区食管癌患
者癌组织中表达水平较高，在有淋巴转移、IIB+III 期以及低分化癌组织中表达水平较高，民族、性别以及年龄对microRNA-21 水
平的影响较小，因此microRNA-21 检测对食管癌的早期诊断及预后判断具有指导意义。 |
| 英文摘要: |
| Objective:To investigate the value of microRNA-21 expression in the early diagnosis and prognosis of esophageal
cancer in Xinjiang.Methods:100 cases with esophageal cancer who were treated in our hospital were selected, including 50 Kazakhs and
50Han populations. Then the expression ofmicroRNA-21 in the serumof patientswas detected by RT-PCRand RTqPCRmethods.Results:The expression of microRNA-21 in cancer tissues was higher than that of paracancerous tissues, and the difference was statistically significant
(P <0.05); The expression of miRNA-21 in patients with lymph node metastasis was higher tan that of the patients without lymph
node metastasis (P<0.05); The expression of miRNA-21 in patients with IIB+III tumor stage was higher than that of the patients with I+IIA
tumor stage (P<0.05); The expression of miRNA-21 in patients high differentiated adenocarcinoma was lower than that of the patients
with low differentiated adenocarcinoma (P<0.05); There was no statistically significant about the expression of miRNA-21 in patients
with different nationalities, gender and ages(P>0.05).Conclusion:The expression of microRNA-21 of Xinjiang patients with esophageal
cancer was higher in lymph node metastasis, IIB+III tumor stage and low differentiated adenocarcinoma. Thus, the detection of microRNA-
21 is valuable for the diagnosis and prognosis of esophageal cancer. |
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