| 李大伟 陈金妮 曹晓琳 张全鹏 罗明英.糖尿病患者外周血Th17/Treg细胞及相关细胞因子的表达变化[J].,2016,16(30):5987-5989 |
| 糖尿病患者外周血Th17/Treg细胞及相关细胞因子的表达变化 |
| Expression of Th17/Treg cells and Related Cytokines in Peripheral Blood ofDiabetes Mellitus Patients |
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| DOI： |
| 中文关键词: 糖尿病 Th17 Treg 细胞因子 |
| 英文关键词: Diabetes mellitus Th17 Treg Cytokines |
| 基金项目:国家自然科学基金项目（81500377）；云南省科技厅-昆明医科大学联合专项（2015FB009） |
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| 中文摘要: |
| 目的：探讨糖尿病患者外周血Th17 细胞和Treg细胞数量以及相关细胞因子表达的变化。方法：以本院2013 年1 月至2015
年12 月收治的50 例糖尿病患者为研究对象，其中1 型糖尿病患者25 例，2 型糖尿病患者25 例，同时以25 例健康体检人群为正
常对照，检测各组外周血Th17/Treg 细胞数量以及血清IL-17、IL-10 和TGF-β水平。结果：糖尿病患者外周血中Th17 细胞比例均
显著高于正常对照组（P<0.05）而Treg细胞的比例均显著低于正常对照组（P<0.05），且1 型糖尿病患者Treg 细胞比例显著低于2
型糖尿病患者（P<0.05）。糖尿病患者血清中IL-10 和TGF-β水平均显著低于正常对照组（P<0.05）而IL-17 水平均显著高于正常对
照组（P<0.05），且1 型糖尿病患者的IL-10水平显著低于2 型糖尿病患者（P<0.05）。结论：糖尿病患者体内Treg 细胞数量及相关
细胞因子低于正常而Th17 细胞数量及相关细胞因子高于正常，这可能与患者体内的自身免疫失调有关。 |
| 英文摘要: |
| Objective:To investigate the changes of the amount of Th17 cell and Treg cell and the expression of related cytokines
in peripheral blood of patients with diabetes mellitus.Methods:In this study, 25 cases of type 1 diabetes patients and 25 cases of type 2
diabetes patients in our hospital between January 2013 and December 2015 were included. There were 25 cases of healthy people as
normal control. All cases got detection of peripheral blood Th17/Treg cell quantity by flow cytometry and serumIL-17, IL-10 and TGF-β
levels by ELISA.Results:The proportion of peripheral blood Th17 cells in diabetic patients were significantly higher than in normal
control group (P<0.05), while the proportion of Treg cells in diabetic patients were significantly lower than in normal control group (P<0.
05) . The proportion of Treg cells in type 1 diabetic patients was significantly lower than in type 2 diabetic patients (P<0.05). The serum
IL-10 and TGF-βlevels were significantly lower in diabetic patients than in normal control group (P<0.05), while the levels of IL-17
were significantly higher in diabetic patients than in normal control group (P<0.05). The serum IL-10 level in patients with type 1
diabetes mellitus was also significantly lower than in type 2 diabetic patients (P<0.05).Conclusion:The proportion of Treg cells and
related cytokines levels in diabetes patients were lower than in normal controls and the proportion of Th17 cells and related cytokines
levels were higher than in normal persons. These changes may be related with the autoimmune disorders of diabetic patients. |
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