| 俞洋 冯丽伟 施荣 欧阳洋 王庆.灯盏花素辅助治疗对急性脑梗死患者的疗效分析[J].,2016,16(30):5917-5920 |
| 灯盏花素辅助治疗对急性脑梗死患者的疗效分析 |
| Effects of Breviscapine in Patients with Acute Cerebral Infarction |
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| DOI： |
| 中文关键词: 灯盏花素 血液流变学 血管内皮功能 凝血功能 急性脑梗死 |
| 英文关键词: Breviscapine Hemorheology Endothelial function Coagulative function Acute cerebral infarction |
| 基金项目: |
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| 中文摘要: |
| 目的：观察灯盏花素辅助治疗对急性脑梗死患者血液流变学、血管内皮功能及凝血功能的影响。方法：选择本院确诊为急性
脑梗死的患者共144 例，包括观察组和对照组各72 例，对照组采用常规对症治疗，观察组在对照组基础上加用灯盏花素静脉滴
注辅助治疗，比较两组患者治疗前后血液流变学、血管内皮功能及凝血功能的差异。结果：经治疗后，观察组NIHSS 评分（3.01±
1.40）显著低于对照组（3.96± 2.17），观察组总有效率显著高于对照组（94.4%vs. 86.1%，P<0.05）。两组间治疗前各指标水平差异未
发现统计学意义（P>0.05）；两组治疗后全血黏度（whole blood viscosity，WBV）、全血还原黏度（whole blood reduced viscosity，
WBRV）、血浆粘度（plasma viscosity，PV）和红细胞聚集指数（erythrocyte aggregation index，EAI）均显著降低（P<0.05）；其中观察组
各个指标均显著低于对照组（P<0.05）；两组治疗后血管内皮素-1（endothelin-1，ET-1）水平与循环内皮细胞（circulating endothelial
cell，CEC）计数显著降低，而一氧化氮（nitrie oxide，NO）及可溶性血栓调节蛋白（soluble thrombomodulin，sTM）水平显著升高（P<0.
05），其中观察组ET-1 水平显著低于对照组，而NO 及sTM 水平显著高于对照组（P<0.05）；两组治疗后凝血酶原时间
（prothrombin time, PT）及部分活化凝血酶原时间（activated partial thromboplastion time, APTT）显著升高，纤维蛋白原（fibrinogen,
Fib）和D-二聚体（D-dimer, DD）显著降低（P<0.05）；其中观察组PT 和APTT显著高于对照组，DD显著低于对照组（P<0.05）。结
论：灯盏花素辅助治疗能有效改善急性脑梗死患者血液粘稠状态，保护血管内皮功能及改善凝血功能。 |
| 英文摘要: |
| Objective:To investigate the effects of breviscapine on hemorheology, endothelial function and coagulative function in
patients with acute cerebral infarction (ACI).Methods:144 patients with ACI were collected and randomly divided into observation
group and control group. The patients in control group were given conventional symptomatic treatments, and the patients in observation
group were given breviscapine intravenous drip on the basis of control group. The hemorheology, endothelial function and coagulative
function were compared between two groups.Results:The NIHSS sore of observation group (3.01± 1.40) was significantly lower than
that of control group (3.96± 2.17) (P<0.05). The effective rate of observation group was significantly higher than that of control group
(94.4% vs. 86.1%, P<0.05). No significantly differences were found in all indexes before treatment between two groups. After different
treatments, whole blood viscosity (WBV), whole blood reduced viscosity (WBRV), plasma viscosity ((PV) and erythrocyte aggregation
index (EAI) in both group was decreased significantly (P<0.05). WBV, WBRV, PV and EAI were all significantly lower in observation
group than that of control group (P<0.05). The level of Endothelin-1 (ET-1) and circulating endothelial cell (CEC) was decreased
significantly after treatment, but nitrie oxide (NO) and soluble thrombomodulin (sTM) was increased significantly (P<0.05). ET-1 level
was lower and NO, sTMwere significantly higher in observation group than that of control group (P<0.05). Prothrombin time (PT) and
thromboplastion time (APTT) was increased significantly after treatment, but fibrinogen (Fib) and D-dimer (DD) decreased significantly
(P<0.05). PT and APTT were higher, and DD were significantly lower in observation group than that of control group (P<0.05).Conclusion:Breviscapine can effectively lower blood viscosity, protect the endothelial function and improve the coagulative function in
patients with ACI. |
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