| 韩仰东 何旺 贾真 张渭涛 姚孝礼.α-D3对原发性肾病综合征患者骨质疏松的预防作用*[J].,2016,16(30):5854-5857 |
| α-D3对原发性肾病综合征患者骨质疏松的预防作用* |
| Effect of a-D3 in Prevention of Osteoporosis for PNS Patientsduring Pred Hormone Treatment |
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| DOI： |
| 中文关键词: α-D3 原发性肾病综合征 Pred 激素 骨质疏松症 |
| 英文关键词: α-D3 PNS Pred hormone Osteoporosis |
| 基金项目:陕西省科技厅自然科学研究计划项目（2009JM4022） |
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| 中文摘要: |
| 目的：探讨α-D3对原发性肾病综合征（PNS）患者Pred 激素治疗过程中发生骨质疏松的影响。方法：收集我院70 例PNS 患
者，随机分为实验组和对照组。对照组给予泼尼松治疗，实验组在对照组基础上给予α维生素D3（α-D3）治疗。观察并比较两组患
者治疗前后骨碱性磷酸酶（NBAP）、抗酒石酸酸性磷酸酶（TRACP）、1，25-（OH）2D3、前甲状腺素原（iPTH）及骨密度水平的变化情
况。结果：与治疗前相比，治疗后两组患者1，25-（OH）2D3及骨密度水平均升高，差异具有统计学意义(P<0.05)；与治疗前相比，治
疗后两组患者NBAP，TRACP 及iPTH水平均降低，差异具有统计学意义(P<0.05)；与对照组比较，实验组患者治疗后1，25-（OH）
2D3及骨密度水平较高，差异具有统计学意义(P<0.05)，与对照组比较，实验组患者治疗后NBAP，TRACP 及iPTH水平较低，差异
具有统计学意义(P<0.05)。结论：琢-D3能够降低原发性肾病综合征患者Pred 激素治疗期间NBAP，TRACP，iPTH水平，提高1，25-
（OH）2D3、骨密度，从而有效预防骨质疏松。 |
| 英文摘要: |
| Objective:To investigate the effect of a-D3 on the prevention of osteoporosis in PNS patients during Pred hormone
treatment.Methods:70 patients with PNS were collected and randomly divided into the experiment group and the control group with 35
cases in each group. The patients in the control group were treated with prednisone, while the patients in the experiment group were
treated with vitamin D3 (α-D3) besides the control group. Then the bone alkaline phosphatase (NBAP), tartrate resistant acid phosphatase
(TRACP), 1, 25- (OH) 2 D3, former thyroid hormone (iPTH) and bone density levels of the two groups were observed and compared.Results:Compared with before treatment, the levels of 1, 25 - (OH) 2 D3 and bone density in the two groups increased after treatment, and
the differences were statistically significant (P<0.05); Compared with before treatment, the levels of NBAP, TRACP and iPTH in the two
groups after treatment decreased, and the differences were statistically significant (P<0.05); Compared with control group after treatment,
the levels of 1, 25-(OH)2 D3 and bone density of the experiment group were higher, and the differences were statistically significant (P<0.
05; Compared with control group after treatment, the levels of NBAP, TRACP and iPTH in the experiment group were lower, and the
differences were statistically significant (P<0.05).Conclusion:α-D3 can decrease the levels of NBAP, TRACP and iPTH of patients with
PNS, and increase the levels of 1, 25- (OH)2 D3 and bone density levels, which would prevent the osteoporosis during Pred hormone
treatment. |
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