杨钢 黎安玲△ 杨桂 徐献群 范维.结直肠癌患者手术前后血清TNF-α, NO, IL-1β、IL-6水平变化及临床意义[J].,2016,16(29):5770-5772 |
结直肠癌患者手术前后血清TNF-α, NO, IL-1β、IL-6水平变化及临床意义 |
The Pre- and Post-operative Changes and Its Clinical Significance of theLevels of TNF-α, NO, IL-1βand IL-6 in Patients with Colorectal Cancer |
|
DOI: |
中文关键词: 结直肠癌 TNF-α NO IL-1β IL-6 |
英文关键词: Colorectal Cancer TNF-alpha NO IL-1beta IL-6 |
基金项目: |
|
摘要点击次数: 633 |
全文下载次数: 0 |
中文摘要: |
目的:探索结直肠癌患者术前术后肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、一氧化氮(nitric oxide,NO)、白细胞介
素-1β(Interleukin-1Beta,IL-1β)、白细胞介素-6 (interleukin-6, IL-6)表达水平的变化及其临床意义。方法:对本院75 例结直肠癌患
者分别采用硝酸还原法及双抗夹心ELISA 法检测手术前后NO及TNF-α、IL-1β、IL-6 表达水平的变化,同时将其与43 例健康体
检者相比较。结果:结直肠癌患者手术前血清中TNF-α、IL-1β、IL-6 浓度(19.45± 4.09,3.91± 0.25,15.93 ± 1.00)明显高于正常对
照组(P<0.05),而NO 浓度(27.5± 5.5)明显低于正常对照组(P<0.05),手术治疗后7 天,TNF-α、IL-1β、IL-6 血清含量(12.31 ±
3.89,1.41± 0.33,9.30± 2.11)明显降低(P<0.05),而NO 含量恢复正常水平。结论:血清中TNF-α、NO、IL-1β、IL-6 浓度与结直肠癌
密切相关,对TNF-α、NO、IL-1β、IL-6 浓度进行联合诊断可作为结直肠癌早期诊断的参考指标。 |
英文摘要: |
Objective:To explore the pre and post-operative changes and its clinical significance of the levels of tumor necrosis
factor-α(TNF-α), nitric oxide(NO), Interleukin-1 Beta (IL-1β) and interleukin-6(IL-6) in patients with Colorectal Cancer.Methods:Nitrate
reduction and double-antibody sandwich ELISA were used respectively to detect the levels of NO and TNF-α, IL-1β, IL-6 in 75
Colorectal Cancer patients, compared with that in control group.Results:In preoperative Colorectal Cancer patients, the levels of serum
TNF-α, IL-1β, IL-6 were significantly higher than those in controls(19.45± 4.09,3.91± 0.25,15.93 ± 1.00)(P<0.05), while the NO level
was significantly lower (27.5± 5.5)(P<0.05). After 7days from operation, the levels of TNF-α, IL-1β, IL-6 were lower than before
(12.31 ± 3.89, 1.41± 0.33, 9.30± 2.11)(P<0.05), and the NO level returned to normal.Conclusion:TNF-α, NO, IL-1β and IL-6 play
important roles in Colorectal Cancer, and they may provide new reference for Colorectal Cancer's early diagnosis. |
查看全文
查看/发表评论 下载PDF阅读器 |
关闭 |
|
|
|