| 付远锋 李家伟 陈阳斌 刘小奇 张龙 李成.阿仑膦酸钠片联合骨碎补煎剂对老年骨质疏松患者血清MMP-9 和
TNF-α水平的影响[J].,2016,16(29):5756-5759 |
| 阿仑膦酸钠片联合骨碎补煎剂对老年骨质疏松患者血清MMP-9 和
TNF-α水平的影响 |
| Effects of Allen Phosphonic Acid SodiumCombined with RhizomaDrynariae Decoction on SerumLevels of MMP - 9 and TNF-α in Patientswith Senile Osteoporosis |
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| DOI： |
| 中文关键词: 阿仑膦酸钠片 骨碎补煎剂 老年骨质疏松 基质金属蛋白酶9 肿瘤坏死因子-α |
| 英文关键词: Allen phosphonic acid sodium Rhizoma drynariae decoction Senile osteoporosis MMP - 9 TNF -α |
| 基金项目:陕西省科技攻关资助项目（2012k16-08） |
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| 中文摘要: |
| 目的：探究阿仑膦酸钠片联合骨碎补煎剂对老年骨质疏松患者血清MMP-9 及TNF-α水平的影响及临床疗效。方法：收集我
院骨科收治的老年骨质疏松患者72 例，根据治疗方法不同分为对照组和试验组，对照组给予阿仑膦酸钠片治疗，试验组在对照
组基础上联用骨碎补煎剂治疗。观察并比较两组患者的临床疗效、骨密度、血清基质金属蛋白酶9(MMP-9)、肿瘤坏死因子-α
(TNF-α)、骨转化指标。结果：试验组临床总有效率（91.67%）显著高于对照组（72.22%），差异具有统计学意义（P＜0.05）。治疗后，两
组患者血清MMP-9，TNF-α、Ⅰ型前胶原氨基端延长肽(TPⅠNP)及Ⅰ型胶原羧基端肽β特殊序列(β-CTX)水平均降低，而甲状旁
腺素(PTH)水平升高，差异具有统计学意义（P＜0.05）；与对照组相比，试验组患者治疗后血清MMP-9，TNF-α、TPⅠNP 及β-CTX
水平较低，而PTH 水平较高，差异具有统计学意义（P＜0.05）。治疗后，两组患者腰椎L2~4、股骨颈、Wards三角区以及股骨大转子
骨密度均升高，差异具有统计学意义（P＜0.05）；治疗后，试验组L2~4、股骨颈骨密度高于对照组，差异具有统计学意义（P＜0.05）。
结论：阿仑膦酸钠片联合骨碎补煎剂对老年骨质疏松患者的临床疗效显著，下调MMP-9 及TNF-α水平，改善骨代谢。 |
| 英文摘要: |
| Objective:To investigate the effect of the allen phosphonic acid sodium combined with Rhizoma drynariae decoction
on the serum levels of MMP - 9 and TNF -αin patients with senile osteoporosis and its clinical curative effect.Methods:72 cases with
senile osteoporosis who were treated in our hospital were selected and according to the different therapeutic methods, the patients were
divided into the control group and the experimental group, with 36 cases in each group. The patients in the control group were treated
with allen phosphonic acid sodium (fosamax), and the patients in the experimental group were treated with rhizoma drynariae decoction
combined with allen phosphonic acid sodium. Then the serum levels of MMP-9 and TNF-α, and the bone density, bone transformation
indexes, the clinical efficacy and the adverse reactions in the two groups were observed and compared before and after the treatment.Results:The clinical efficacy rate of the experiment group was 91.67%, which was higher than 72.22% of the control group, and the difference
was statistically significant (P<0.05); Compared with before treatment, the serum levels of MMP-9, TNF-α, TPⅠNP and β-CTX in the
two groups after the treatment decreased, while the levels of PTH increased, and the differences were statistically significant (P<0.05);
Compared with the control group after treatment, the serum levels of MMP-9, TNF-α, TPⅠNP and β-CTX in the experiment group were
lower, while the level of PTH was higher, and the differences were statistically significant (P<0.05); Compared with before treatment, the
bone density of L2 ~ 4, femoral neck and Ward's triangle region and trochanter of femur in the two groups increased, and the differences
were statistically significant (P<0.05); Compared with the control group after treatment, the bone density of L2 ~ 4 and femoral neck were
higher, and the difference was statistically significant (P<0.05); There was no statistically significant difference about the adverse reactions
between the two groups (P>0.05).Conclusion:Allen phosphonic acid sodium combined with Rhizoma drynariae decoction has better
effect on the treatment of senile osteoporosis which can reduce the serum levels of MMP-9 and TNF-α, and improve the bone
metabolism. |
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