| 孟胜楠 张若溪 陈树源 侯静波 董玲 王楠.基质细胞衍生因子-1 与围生期心肌病患者心力衰竭的相关性研究[J].,2016,16(28):5531-5535 |
| 基质细胞衍生因子-1 与围生期心肌病患者心力衰竭的相关性研究 |
| Relationship between the Circulating Stromal Cell-derived Factor-1 andHeart Failure in Patients with PeripartumCardiomyopathy |
| |
| DOI： |
| 中文关键词: 围生期心肌病 心力衰竭 基质细胞衍生因子-1 |
| 英文关键词: Peripartumcardiomyopathy Heart failure Stromal cell-derived factor-1 |
| 基金项目:国家自然科学基金青年基金项目(30700765) |
|
| 摘要点击次数: 587 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：探讨基质细胞衍生因子-1与围生期心肌病患者心力衰竭的相关性。方法：采用前瞻性研究纳入59 例围生期心肌病并
发心力衰竭患者，33 例单纯围生期心肌病患者作为对照组。患者均接受体检、实验室检查、心电图、心脏彩超评估。选取基质细胞
衍生因子-1(SDF-1)、超敏C 反应蛋白(hs-CRP)、氨基末端脑钠肽前体(NT-proBNP)、血清肌钙蛋白(TNI)及心脏彩超相关参数为评
价指标。结果：(l)围生期心肌病患者循环中基质细胞衍生因子-1 水平明显高于对照组；(2)循环中基质细胞衍生因子-1 与超敏C
反应蛋白(CRP)、氨基末端脑钠肽前体(NT-proBNP)呈正相关，与超声心动图左心室射血分数(LVEF)呈负相关。结论：基质细胞衍
生因子-1 与围生期心肌病患者心力衰竭具有显著相关性。 |
| 英文摘要: |
| Objective:To assess the relationship between circulating SDF-1 level and heart failure in patients with peripartum
cardiomyopathy (PPCM).Methods:The circulating SDF-1 level and other clinical variables including N-terminal pro-brain natriuretic
peptide (NT-proBNP), hypersensitivity C-reactive (hs-CRP) and echocardiographic parameters were measured in PPCM patients
combined with heart failure (n=59) and simple PPCM (control subjects) (n=33).Results:The circulating SDF-1 level was significantly
higher in patients with PPCM combined with heart failure (5018± 854 pg/mL) compared with the control subjects (1879± 752 pg/ml,
P<0.001). The circulating SDF-1 level was positively correlated with the NT-proBNP (r=0.634, P<0.001) and hs-CRP (r=0.311, p=0.017)
levels and negatively correlated with the left ventricular ejection fraction values (r= 0.889, P<0.001).Conclusion:The level of circulating
SDF-1 increased in PPCMpatients with heart failure and had significant correlation with PPCMcombined with heart failure. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
