| 李家庚 魏登科 李刚 王强 周运平.新辅助化疗结合保肢手术治疗骨肉瘤的临床疗效[J].,2016,16(28):5468-5471 |
| 新辅助化疗结合保肢手术治疗骨肉瘤的临床疗效 |
| Clinical Efficacy of Neoadjuvant Chemotherapy Combined with LimbSalvage Surgery for Osteosarcoma |
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| DOI： |
| 中文关键词: 骨肉瘤 新辅助化疗 保肢手术 临床疗效 |
| 英文关键词: Osteosarcoma Neoadjuvant chemotherapy Limb salvage surgery Clinical curative effect |
| 基金项目:陕西省自然科学基金项目(2009CDB333) |
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| 中文摘要: |
| 目的：探讨骨肉瘤新辅助化疗结合保肢手术的临床疗效。方法：收集我院就诊或住院治疗的50例骨肉瘤患者，随机分为实验
组和对照组，每组25 例。对照组患者采用囊外彻底切除，对瘤体以及周围正常组织5 cm以上进行根治性切除术；实验组患者行
保肢手术术前以及术后行新辅助化疗。治疗过程中对患者的不良反应进行及时治疗。治疗结束后，对患者肿瘤复发率、转移率、生
存状况、肢体功能以及患者临床疗效进行评价。结果：与对照组相比，实验组患者术后的复发率、转移率较低（P<0.05），3 年生存率
以及肢体功能的优良率较高（P<0.05），临床治疗有效率较高（P<0.05）。结论：新辅助化疗结合保肢手术能够降低骨肉瘤患者的术
后复发率和转移率、改善患者的生存状况、肢体功能，临床疗效较好，对临床有指导意义。 |
| 英文摘要: |
| Objective:To investigate the clinical efficacy of neoadjuvant chemotherapy combined with limb salvage surgery in the
treatment of osteosarcoma.Methods:in each group. The patients in control group were treated with radical resection of tumor and
surrounding normal tissue more than 5 cm, and the patients in experimental group were treated with neoadjuvant chemotherapy before
and after limb salvage surgery based on control group. The adverse reactions of the patients in the treatment process were treated. After
treatment, the recurrence rate, metastasis rate, survival status, physical function and clinical efficacy were observed and compared
between the two groups of patients.Results:Compared with the control group, the recurrence rate and metastasis rate were lower in
experimental group (P < 0.05), and the 3 years survival rate, the excellent and good rate of limb function were higher (P < 0.05), and the
clinical effective rate was higher (P < 0.05) in the experimental group.Conclusion:Neoadjuvant chemotherapy combined with limb
salvage surgery for osteosarcoma patients has good clinical curative effect which can reduce the postoperative recurrence rate and
metastasis rate, improve the patients' survival and limb function. |
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