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目的：调查安康地区女性人乳头瘤病毒（HPV）感染的基因型别及年龄分布特征，分析其与宫颈癌的关系，为宫颈癌防治及 HPV 疫苗研发提供可靠的依据。方法：收集2010 年6 月-2012 年8 月间在本院及安康市部分县级医院妇产科就诊的2736 名女性的液基细胞学和组织学标本，分为8 个年龄组：16-24 岁119 例、25-29 岁230 例、30-34 岁343 例、35-39 岁472 例、40-44 岁574 例、45-49 岁512 例、50-54 岁206 例、55-86岁280 例，进行病理学分类及HPV 分型检测，分析不同年龄组及不同类型宫颈组织中的HPV感染率。结果：2736 例女性中发生HPV 感染720 例（26.32%），共检出21 种型别，感染率最高的基因型别是HPV16 （25.05%），其他常见型别依次为HPV58、HPV52、HPV6、HPV11。单一感染占76.25%，多重感染占23.75%。HPV 感染率在16-24 岁、35-39 岁和55-86 岁三个年龄段出现高峰；而高危型HPV 的感染率在35-39 岁和55-86 岁两个年龄段分别出现高峰。HPV 的检出率随着宫颈病变的严重程度而增加，其中正常或炎症人群的HPV 感染率显著低于宫颈病变及宫颈鳞状细胞癌患者（均P＜ 0.05），且意义未明的不典型鳞状细胞（ASCUS）、CIN1-3 及宫颈鳞状细胞癌患者的HPV 感染率对比结果存在显著差异（P＜ 0.05）。CIN1 组、CIN2-CIN3 组及宫颈鳞状细胞癌组单一感染率逐渐增加（P<0.05），且其二重、三重感染率比较差异均有统计学意义（P<0.05）。结论：安康地区HPV16 型别感染较广，临床需加强对HPV16 型单一感染宫颈病变患者的癌症预防工作。

英文摘要:

Objective:To investigate the distribution characteristics of genotype and age in women with human papilloma virus (HPV)infection in Ankang area, and analyze its relationship with cervical cancer,in order to offer evidence for cervical cancer prevention and HPV vaccine research.Methods:Collected liquid-based cytology/histology specimens of 2736 women who treated in the department of obstetrics and gynecology in our hospital and other county hospitals from June 2010 to August 2012,they were divided into 8 age groups: 16-24 years old group with 119 cases,25-29 years old group with 230 cases, 30-34 years old group with 343 cases, 35-39 years old group with 472 cases, 40-44 years old group with 574, 45-49 years old group with 512 cases, 50-54 years old group with 206 cases, and 55-86 years old group with 280 cases, performed the pathology classification and HPV typing detection,then analyzed the HPV infection rates in different age groups and different types of cervical tissues.Results:There were 720 women with HPV infection in 2736 women (26.32%), 21 genotypes were detected, the highest infection rate subtypes was HPV16 (25.05%), followed by the genotypes of HPV58,HPV52, HPV6, HPV11. The single infection accounting for 76.25%, multiple infections accounted for 23.75%. The peak of HPV infection rate distributed in 16-24, 35-39 and 55-86 years old groups, and the peak of high risk HPV type infection rate distributed in 35-39 and 55-86 years old groups.The HPV infection rate was increase alone with the severity of cervical lesions,the HPV infection rate in normal or inflammatory people was significantly lower than patients with cervical lesions and cervical squamous cell carcinoma(P<0. 05),and the HPV infection rate in patients with atypicai squamous cells of unknown significance (ASCUS), CIN 1-3 stage and cervical squamous cell carcinoma had significant difference (P<0.05). The single infection rate in CIN1 group, CIN2-CIN3 group and cervical squamous cell carcinoma gradually increased (P<0.05), and the double and triple infection rate in three groups had significant difference (P<0.05).Conclusion:HPV16 infection is popular in Ankang area, it is suggest to strengthen the cancer prevention for cervical lesions patients with HPV16 single infection.

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