| 张文 解为慈△ 徐金娥 刘文 张先君.非布司他对痛风合并高尿酸血症患者血清sICAM-1, ET-1 及尿酸水平的影响[J].,2016,16(27):5303-5305 |
| 非布司他对痛风合并高尿酸血症患者血清sICAM-1, ET-1 及尿酸水平的影响 |
| Effects of Febuxostat on the SeumsICAM-1, ET-1 and Uric Acid Levels ofPatients with Gout and Hyperuricemia |
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| DOI： |
| 中文关键词: 非布司他 痛风 高尿酸血症 内皮素-1 细胞间粘附分子-1 尿酸 |
| 英文关键词: Febuxostat Gout Hyperuricemia Endothelin -1 Intercellular adhesion molecule-1 Uric acid |
| 基金项目:湖北省自然科学基金项目(2002AB116) |
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| 中文摘要: |
| 目的：探讨非布司他对痛风合并高尿酸血症患者血清内皮素-1(ET-1)、细胞间粘附分子-1(ICAM-1)及尿酸水平的影响。方
法：收集在我院就诊或住院治疗的80 例痛风合并高尿酸血症患者，随机分为实验组和对照组，每组40 例。对照组患者给予别嘌
呤醇片治疗；实验组患者给予非布司他片治疗。观察并比较两组患者治疗前后血尿酸、sICAM-1、ET-1 水平及临床疗效。结果：与
治疗前相比，两组患者治疗后的血尿酸、sICAM-1、ET-1 水平均显著降低(P<0.05)；与对照组相比，实验组患者的血尿酸、sICAM-1、
ET-1 水平较低(P<0.05)，临床治疗总有效率较高(P<0.05)。结论：非布司他能够降低痛风合并高尿酸血症的sICAM-1、ET-1 及尿酸
水平，且临床疗效较好。 |
| 英文摘要: |
| Objective:To evaluate the effect of febuxostat on gout and hyperuricemia, uric acid and Endothelin -1(ET-1) and intercellular
adhesion molecule -1 (ICAM-1).Methods:Collected in our hospital or hospital treatment of 80 cases of gout and hyperuricemia
were randomly divided into experimental group and control group, 40 cases in each group. Patients in control group were treated with 0.1
g/ times, 3 times /d, oral; the experimental group were given times 80mg/ times, 1 times /d, oral administration. Treatment for 8 consecutive
weeks. After the end of the treatment, the blood uric acid, sICAM-1, ET-1 and the patients' curative effect were detected and compared.Results:Compared with that before treatment and after treatment of two groups of patients with blood uric acid, sICAM-1 and
ET-1 levels lower (P<0.05); compared with the control group, blood uric acid, sICAM-1 and ET-1 levels of the patients in the experimental
group were lower (P<0.05), clinical treatment and the total effective rate was higher (P<0.05).Conclusion:Febuxostat can reduce
gout and hyperuricemia, uric acid and sICAM-1 ET-1, clinical curative effect is good, has the guiding sense to the clinical. |
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