| 李学庆 王晖 汤承辉 柯文才 刘启岑 史永照 沈芳.血浆HSP60 和TSGF联合检测甲状腺癌的早期诊断价值[J].,2016,16(27):5293-5295 |
| 血浆HSP60 和TSGF联合检测甲状腺癌的早期诊断价值 |
| Early Diagnostic Value of Combined Detection of Plasma HSP60 and TSGFon Thyroid Cancer |
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| DOI： |
| 中文关键词: 甲状腺癌 HSP60 TSGF 联合检测 早期诊断 |
| 英文关键词: Thyroid cancer HSP60 TSGF Combined detection Early diagnosis |
| 基金项目:上海市闵行区科学技术委员会科研项目（2015MHZ033） |
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| 中文摘要: |
| 目的：究血浆热休克蛋白-60（HSP60）与肿瘤特异性生长因子（TSGF）联合检测对甲状腺癌的早期诊断价值。方法：于2011
年1 月~2015 年11 月期间选取254 例甲状腺癌患者（定为甲状腺癌组）、156 例结节性甲状腺肿患者（结节性甲状腺肿组）和202
例健康者（健康组）为研究对象，采用ELISA 法检测三组血浆HSP60、TSGF水平，分析其与甲状腺癌病理因素的关系及诊断的敏
感度和特异度。结果：甲状腺癌组的血浆HSP60、TSGF水平均显著高于结节性甲状腺肿组以及健康组，且结节性甲状腺肿组高于
健康组，差异均具有统计学意义（P＜0.05）。甲状腺癌患者血浆HSP60 、TSGF 水平与年龄、性别、临床分期均无相关性（P＞0.05）。
血浆HSP60、TSGF单独诊断甲状腺癌的敏感度和特异度分别为68.75%、81.82%和83.33%、71.88%，两者联合诊断的敏感度和特
异度则分别达到了88.89%和86.72%。结论：在甲状腺癌的早期诊断中，采用血浆HSP60 和TSGF联合检测的方式可靠性较高，值
得推广应用。 |
| 英文摘要: |
| Objective:To explore the early diagnostic value of combined detection of plasma heat shock protein 60 (HSP60) and
tumor specific growth factor(TSGF) on thyroid cancer.Methods:Selected 254 patients with thyroid cancer(as thyroid cancer group), 156
patients with nodular goiter (as nodular goiter group) and 202 healthy subjects (as healthy group) as the research objects, then detected the
plasma HSP60, TSGF levels in three groups by ELISA method, analyzed their correlation with pathological factors in thyroid cancer
group and the sensitivity and specificity.Results:The plasma HSP60, TSGF levels in thyroid cancer group were significantly higher than
nodular goiter group and healthy group, which levels in nodular goiter were also higher than healthy group, the differences were statistically
significant(P<0.05). There was no correlation between plasma HSP60, TSGF levels and age, gender and clinical stage(P>0.05). The
sensitivity and specificity of dividually plasma HSP60 and TSGF in the diagnosis of thyroid cancer were respectively 68.75%, 81.82%
and 83.33%, 71.88%, while the combined detection reached 88.89% and 86.72%.Conclusion:In the early diagnosis of thyroid cancer,
the combined detection of plasma HSP60 and TSGF has higher reliability, it is worthy of popularization and application. |
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