| 邓亚平 钟晶敏 李晶 刘文斌 张芸 黄三钱 刘志红 曾亮.Fas 相关死亡结构域蛋白在乳腺癌中表达的临床病理研究[J].,2016,16(26):5068-5071 |
| Fas 相关死亡结构域蛋白在乳腺癌中表达的临床病理研究 |
| Clinicopathological Study on the Expression of Fas-associated Death Domain Protein in Breast Cancer |
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| DOI： |
| 中文关键词: Fas 相关死亡结构域蛋白 乳腺癌 临床病理 |
| 英文关键词: Fas-associated death domain protein Breast cancer Clinicopathology |
| 基金项目:湖南省科学技术厅科技计划专项项目（2014FJ6090） |
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| 中文摘要: |
| 目的：探讨Fas 相关死亡结构域蛋白（Fas-associated death domain protein，FADD）在乳腺癌中表达的临床病理学意义。方法：
收集乳腺癌病例及相应的临床资料包括随访资料，应用免疫组织化学技术检测乳腺良性病变，有/ 无淋巴结转移的乳腺癌及配对
淋巴结转移灶中FADD 的表达，观察分析FADD 表达与乳腺癌患者年龄、肿块大小、临床分期、组织学类型和分级、雌孕激素受体
水平等临床病理指标间的关系。结果：免疫组化检测结果显示良性乳腺病变组中FADD的阳性表达率（85.1%，40/47）与无淋巴结
转移的乳腺癌组（45.8%，38/83），伴有淋巴结转移的乳腺癌组（67.3%72/107）和淋巴结转移灶（45.8%，49/107）组织中FADD 阳性
表率均有显著性差异（P值分别<0.001，=0.022 和<0.001）；此外，伴有淋巴结转移的乳腺癌组中FADD阳性表达率也均与其它三
组中FADD阳性表达率之间具有显著性差异（P 值分别为0.003，<0.001 和0.022）。FADD与患者的确诊年龄（P =0.049）和淋巴结
转移有显著性相关（P =0.003），与肿瘤大小、临床分期、组织学类型、组织学分级、雌孕激素受体及cerb B-2 的表达情况和月经史
无明显相关性（P >0.05）。生存分析显示FADD阳性表达的患者较FADD 阴性患者的生存期更短。结论：FADD与乳腺癌淋巴结转
移和预后有关。 |
| 英文摘要: |
| Objective:To investigate the clinicopathological significance of Fas-associated death domain protein (FADD)
expression in breast cancer.Methods:The clinical data of breast cancer cases and relevant clinical data were collected. The expression of
FADD in breast benign lesion, breast cancer with or without lymph node metastasis and paired lymph node metastasis was detected by
immunohistochemical technique. The relationship between FADD expression and clinical pathological parameters of breast cancer
patients, such as age, tumor size, clinical stage, histological type and grade, estrogen and progesterone receptor level, and so on was
analyzed.Results:Immunohistochemistry results showed FADD positive expression rate of benign breast lesion group (85.1%, 40/47),
breast cancer group without lymph node metastasis (45.8%, 38/83), breast cancer group with lymph node metastasis(67.3%,72/107) and
paired lymph metastasis foci (45.8%, 49/107). There are significant difference between breast cancer without metastasis, breast cancer
with metastasis, lymph node foci and benign breast lesion group (respectively P < 0.001, = 0.022, < 0.001); in addition, FADD positive
expression rate of breast cancer grou with lymph node metastasis was higher than the other three groups (P = 0.003, < 0.001 and 0.022,
respectively). FADD expression is significantly associated with the patient's age at diagnosis (P = 0.049) and lymph node metastasis (P =
0.003), and there is significant correlation to tumor size, clinical staging, histological type, histological grade, estrogen and progesterone
receptors and c-erbB-2 expression situation and menstrual history (P > 0.05). Survival analysis showed that patients with FADD positive
expression had shorter survival time than FADD negative patients.Conclusion:FADD is associated with lymph node metastasis and
prognosis of breast cancer. |
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