| 杨晨 邓子辉 靳丽媛 张泽宇 陈光辉 司艺玲.间充质干细胞治疗糖尿病心脏病研究进展及其机制[J].,2016,16(25):4992-4996 |
| 间充质干细胞治疗糖尿病心脏病研究进展及其机制 |
| Process and Mechanism of Mesenchymal StemCells in the Treatment ofDiabetic Cardiomyopathy |
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| DOI： |
| 中文关键词: 糖尿病心脏病 间充质干细胞 发病机制 治疗机制 |
| 英文关键词: Diabetic cardiomyopathy Mesenchymal stemcells Pathogenesis Treatment mechanism |
| 基金项目:国家自然科学基金项目（81471052） |
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| 中文摘要: |
| 糖尿病心脏病（diabetic cardiomyopathy，DCM）患者心脏病变弥漫、病变程度严重，患病率与死亡率逐年上升，缺乏有效的治
疗手段，找到其他的治疗途径已成为一项重要内容。有研究发现，间充质干细胞（mesenchymal stemcells，MSCs）作为一种具有多
分化潜能的细胞，能够通过多种机制作用于DCM的病理改变，提高心脏射血分数、改善心室重塑，是一种富有前景的治疗手段，
本文着重就DCM的发病机制、MSCs 对DCM的治疗机制及效果做一综述，为MSCs在DCM治疗中的应用提供重要的临床前实
验依据。 |
| 英文摘要: |
| The patients with diabetic cardiomyopathy (DCM) process the wider and more severe cardiac pathological changes.
Its increasing morbidity and mortality rate and lack of effective therapy lead to a necessity of finding other treatments. Mesenchymal stem
cells (MSCs) with the multiple differentiation potentials can influence on DCMthrough various mechanisms, improving cardiac ejection
fraction and ventricular remodeling. It is regarded as a promising therapy. The pathogensis of DCMand the treatment mechanisms are focused
in this review to provide pre-clinial basis for DCM. |
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