| 王亚儒 唐孝良 陈永乐 王世霞 姚远 闫平权 李晶.结直肠癌肝转移原发病灶切除后患者生存状况及预后因素分析[J].,2016,16(25):4922-4925 |
| 结直肠癌肝转移原发病灶切除后患者生存状况及预后因素分析 |
| Survival Status and Prognostic Factors of Colorectal Cancer Liver Metastasesafter Resection of the Primary Tumors |
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| DOI： |
| 中文关键词: 结直肠癌 肝转移 生存状况 预后因素 |
| 英文关键词: Colorectal cancer Liver metastases Survival status Prognostic factors |
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| 中文摘要: |
| 目的：探讨结直肠癌肝转移原发病灶切除后患者生存状况及预后因素分析。方法：回顾性分析2008 年5 月至2012 年5 月
我院收治的60 例结直肠癌肝转移并接受原发病灶切除术患者临床及随访资料。采用Kaplan-Meier 方法计算中位生存时间，采用
Log-rank 检验进行单因素分析，采用Cox 回归模型进行多因素分析，对影响结直肠癌肝转移原发病灶切除后患者预后的相关因
素进行分析。结果：60 例患者1、2、3 年生存率分别为83.2 %、67.8 %及50.3 %；中位生存时间为（22.9± 5.56）个月。单因素分析结
果显示，原发肿瘤形态学分型、原发肿瘤T 分期、原发肿瘤N 分期、原发病灶手术方式、肝转移时间以及肝转移灶局部治疗方式等
6 个临床因素是结直肠癌肝转移原发病灶切除患者预后的影响因素（P<0.05）。多因素分析结果显示，影响结直肠癌肝转移原发病
灶切除后患者预后的因素主要有原发肿瘤形态学分型、原发病灶手术方式以及肝转移灶局部治疗方式（P<0.05）。结论：原发肿瘤
形态学分型、原发病灶手术方式以及肝转移灶局部治疗方式是影响结直肠癌肝转移患者预后的主要因素。对结直肠癌肝转移患
者进行早期明确诊断与手术治疗，并对肝转移灶局部设定合理治疗方案，对于患者生存状况的提高具有十分积极的意义。 |
| 英文摘要: |
| Objective:To explore the survival status and prognostic factors of colorectal cancer liver metastases after resection of
the primary tumors.Methods:60 patients with colorectal cancer liver metastases underwent resection of the primary tumors in our hospital
fromMay 2008 to May 2012 were retrospective analyzed. The median survival time was calculated by Kaplan-Meier, and the single-factor
analysis and multi-factor analysis were calculated by Log-rank and Cox regression model respectively to analyze the prognostic factors
of colorectal cancer liver metastases after resection of the primary tumors.Results:The survival rate of 1-, 2-, 3-years of 60 patients
were 83.2 %, 67.8 %and 50.3 %respectively, and the median survival time was（22.9± 5.56）months. The single-factor analysis showed
that morphology, T stage, N stage and operation type of primary tumors, liver metastases time and treatment of liver metastasis focus
were the prognostic factors of patients with colorectal cancer liver metastases (P<0.05). The multi-factor analysis showed that morphology
and operation type of primary tumors and treatment of liver metastasis focus were the major prognostic factors (P<0.05).Conclusion:The morphology and operation type of primary tumors and treatment of liver metastasis focus were the major prognostic factors of colorectal
cancer liver metastases, so it is important to make early definitive diagnosis, surgical treatment and to design reasonable treatment
methods of liver metastasis focus to these patients, which has a positive effect in improving the survival status of patients. |
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