| 王少丽 董晋△ 张明 吕鑫荣 白金博.TNF-α, NF-KBp65, PAI-1 在妊娠期糖尿病孕妇血清及胎盘组织中的表达
变化及其意义[J].,2016,16(25):4867-4869 |
| TNF-α, NF-KBp65, PAI-1 在妊娠期糖尿病孕妇血清及胎盘组织中的表达
变化及其意义 |
| Expression of TNF-α, NF-KBp65 and PAI-1 in Serumand Placental Tissueof Gestational Diabetes Pregnant Women |
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| DOI： |
| 中文关键词: TNF-α NF-KBp65 PAI-1 妊娠期糖尿病 酶联免疫吸附试验 |
| 英文关键词: TNF-α NF-KBp65 PAI-1 Gestational diabetes mellitus Enzyme-linked immunosorbent assay |
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| 中文摘要: |
| 目的：探究TNF-α、NF-KBp65 以及PAI-1在妊娠期糖尿病孕妇血清和胎盘组织中的表达变化及其临床意义。方法：选取自
47 例定期产检并且住院分娩的妊娠期糖尿病孕妇作为观察组，再选取同期分娩的47 例正常孕妇作为对照组，比较两组孕妇血清
和胎盘组织中TNF-α、NF-KBp65和PAI-1 的表达水平，并分析血清中TNF-α、NF-KBp65、PAI-1 表达水平的相关性。结果：观察组
孕妇血浆的TNF-琢和PAI-1表达水平明显较高，差异具有统计学意义（P均＜0.001）。妊娠期糖尿病患者血浆中PAI-1 表达水平
和TNF-琢表达水平呈正相关关系（r=0.843，P＜0.001）。观察组孕妇的空腹-OGTT、1h-OGTT、2h-OGTT、空腹胰岛素、空腹血糖以
及胰岛素抵抗指数均明显高于对照组（P均＜0.001）。胰岛素抵抗指数与妊娠期糖尿病患者血浆中TNF-α的表达水平相关性最高
（Beta=0.769）；口服葡萄糖耐受实验中1-h 的血糖水平与PAI 的表达水平相关性最高（Beta=0.637）。观察组孕妇的TNF-α、
NF-KBp65 和PAI-1 的阳性率显著高于对照组，差异具有统计学意义（P＜0.001，=0.039,0.007）。结论：血清和胎盘组织中的
TNF-α、NF-KBp65 和PAI-1 可能参与了妊娠期糖尿病的发生与发展。 |
| 英文摘要: |
| Objective:To investigate the expression changes of TNF-α, NF-KBp65 and PAI-1 in serum and placental tissue of
gestational diabetes pregnant women, as well as its clinical significance.Methods:Select 47 regular prenatal and hospital childbirth gestational
diabetes pregnant women as observation group, and select 47 cases of normal pregnant women in childbirth at the same period as
the control group. Compare the expression levels of TNF-α, NF -KBp65 and PAI-1 in serumand placental tissue between the two groups,
and analyze the correlation of the expression levels of serum TNF-α, NF-KBp65 and PAI-1.Results:The expression levels of serum
TNF-琢and PAI-1 were higher in pregnant women of observation group, with statistically significant difference (P<0.001). In plasma of
patients with gestational diabetes, the expression levels of PAI-1 were positively correlated with the TNF-αexpression levels (r=0.843,
P<0.001). In observation group, the empty stomach-OGTT, 1 h-OGTT, 2h-OGTT, fasting insulin, fasting plasma glucose and insulin resistance
indexes were significantly higher than in control group (P<0.001). Insulin resistance index had the highest correlation with the
expression levels of TNF-αin plasma of patients with gestational diabetes (Beta = 0.769). Oral glucose tolerance test, the 1-h blood glucose
levels had the highest correlation with the expression level of PAI (Beta=0.637). In observation group, the pregnant women had
higher positive rates of TNF-α, NF-KBp65 and PAI 1 than in control group, and differences had statistical significance (P<0.001=0.039,
0.001).Conclusion:TNF-α, NF-KBp65 and PAI-1 in the serum and placental tissues might participate in the onset and development of
gestational diabetes mellitus. |
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