| 贾文丽 张林 程淑杰 李冬梅 张昕.2 型糖尿病患者凝血功能水平与血管病变发生的相关性[J].,2016,16(24):4767-4769 |
| 2 型糖尿病患者凝血功能水平与血管病变发生的相关性 |
| Relationship between Coagulation Function and Vascular Disease in Patientswith Type 2 Diabetes Mellitus |
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| DOI： |
| 中文关键词: 2型糖尿病 血管病变 凝血功能 TNF-α IL-18 |
| 英文关键词: Type 2 diabetes Vascular disease Coagulation function TNF-α IL-18 |
| 基金项目:内蒙古自治区自然科学基金项目（2010114） |
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| 中文摘要: |
| 目的：探讨2 型糖尿病患者凝血功能及血清肿瘤坏死因子α（TNF-α）及白细胞介素18（IL-18）水平与糖尿病血管病变的关
系。方法：选择2014 年6 月-2015 年10 月在我院接受治疗的2 型糖尿病患者83 例作为研究对象，根据患者疾病进展情况将其分
为血管病变组（45 例）和无血管病变组（38 例）。测定两组患者凝血酶时间（TT）、活化部分凝血酶原时间（APTT）、凝血酶原时间
（PT）、纤维蛋白原（Fg）、血糖（Glu）、糖化血红蛋白（HbA1c）、肿瘤坏死因子α（TNF-α）及白细胞介素18（IL-18）水平；采用logistics
回归分析2 型糖尿病患者发生血管病变的危险因素。结果：血管病变组患者Glu，HbA1c 及Fg水平均显著高于无血管病变组，而
APTT 及PT 水平均显著低于无血管病变组，差异均具有统计学意义（P<0.05）；两组间TT水平比较，差异无统计学意义（P>0.05）。
血管病变组患者血清中TNF-琢及IL-18 水平均高于无血管病变组患者，差异具有统计学意义（P<0.05）。HbA1c，Fg，TNF-琢以及
IL-18 水平异常是2 型糖尿病患者发生血管病变的独立危险因素（OR=1.23，1.45，2.632，3.884，P<0.05）。结论：凝血功能紊乱及炎
症反应是2 型糖尿病患者发生血管病变的重要因素，临床应给予重视。 |
| 英文摘要: |
| Objective:To explore the relationship between coagulation function and serum TNF-α and IL-18 levels and vascular
lesions of patients with type 2 diabetes.Methods:83 patients with type 2 diabetes who were treated in our hospital from June 2014 to
October 2015 were selected as the research objects, and according to the progress of the disease, the patients were divided into the
vascular lesion group (45 cases) and the non vascular lesion group (38 cases). Then the thrombin time (TT), activated partial
thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FG), glucose (Glu), glycosylated hemoglobin (HbA1c) and serum
TNF-α and IL-18 levels were detected, and the risk factors of vascular disease in type 2 diabetes was analyzed by logistic regression
analysis.Results:The levels of Glu, HbA1c and Fg in the vascular lesion group were significantly higher than those of the non vascular
lesion group, and the levels of APTT and PT were significantly lower, and the differences were statistically significant (P<0.05). There
was no significant difference in the level of TT between the two groups (P>0.05). The levels of IL-18 and TNF-琢in the serumof vascular
lesion group were higher than those of the non vascular lesion group, and the differences were statistically significant (P<0.05).
Independent risk factors for vascular disease were the levels changes of HbA1c, Fg, TNF-α and IL-18 (P<0.05).Conclusion:Coagulation
disorders and inflammatory response is an important factor in the occurrence of vascular disease in patients with type 2 diabetes, which
should pay more attention. |
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