| 初明 刘彦辰 张明波 初正云 徐兰 周鹏 杨柯 马小龙 陈晓芹 梁秀军 王月丹.盐酸小檗碱缓释片的研制[J].,2016,16(23):4415-4418 |
| 盐酸小檗碱缓释片的研制 |
| Study on Preparation of Berberine Hydrochloride Sustained-release Tablets |
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| DOI： |
| 中文关键词: 盐酸小檗碱 缓释片 释放度 体外释放 |
| 英文关键词: Berberine hydrochloride Sustained-release tablets Release rate In vitro release |
| 基金项目:北京市重点学科基础医学学科建设项目（BMU20110254）；国家基础科学人才培养基金（J1030831/ J0108）；
北京大学创新人才培养计划 |
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| 中文摘要: |
| 目的：研究盐酸小檗碱缓释片的配方与制备方法，考察其释放度。方法：以盐酸小檗碱释放度为考察指标，采用单因素试验
法，考察了羟丙基甲基纤维素(HPMC)和乳糖的用量对药物体外释放行为的影响，并采用正交设计实验对处方进行优化，确定最
佳处方。结果：最佳配方为HPMC-K4M的用量为10 %，乳糖用量为20 %，PVP 的用量为3 %，微晶纤维素的用量为20 %。2 h累
积释药量为30 %，6 h累积释药量为60 %，12 h 累积释药量为90 %。结论：按最佳配方制备的盐酸小檗碱缓释片有较好的缓释行
为，基本上能满足缓释片的释放要求。 |
| 英文摘要: |
| Objective:Study the formulation and preparation methods of Berberine hydrochloride sustained-release tablets, and investigate
its release rate.Methods:With the release rate of Berberine hydrochloride as investigation index, using single factor test
method, studied the impact of the amount of hydroxypropyl methyl cellulose (HPMC,) and lactose on release behavior in vitro drug, and
determined the best prescription by orthogonal design to the optimize prescription.Results:Best formula is: HPMC-K4Min an amount of
10 %, the amount of lactose 20 %, PVP in an amount of 3 %, microcrystalline cellulose in an amount of 20 %. 2 h accumulated release
amount is 30 %, 6 h cumulative release amount of 60 %, and 12 h accumulated release amount is 90 %.Conclusion:Berberine hydrochloride
sustained-release tablets prepared according to the best recipes have better release behavior, can basically meet the requirements
of sustained-release tablets. |
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