| 丁伟平 赵修义 杨立慧 田军 张昆.131I对男性甲状腺功能亢进症血清性激素及甲状腺球蛋白水平影响研究[J].,2016,16(22):4355-4358 |
| 131I对男性甲状腺功能亢进症血清性激素及甲状腺球蛋白水平影响研究 |
| A Study on the Effect of 131I on the SerumSex Hormones and ThyroglobulinLevels of Male Patients with Hyperthyroidism |
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| DOI： |
| 中文关键词: 131I 甲状腺功能亢进症 睾酮(T) 雌二醇(E2) 甲状腺球蛋白(TG) |
| 英文关键词: 131I Hyperthyroidism T E2 TG |
| 基金项目:山东省自然科学基金项目(ZR2012HM005) |
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| 中文摘要: |
| 目的：探讨131I 对男性甲状腺功能亢进症患者血清性激素及甲状腺球蛋白水平的影响。方法：收集我院收治的男性甲状腺功
能亢进症患者74 例，随机分为对照组和实验组，每组各37例，对照组患者给予他巴唑口服，20-30 mg/次，每日口服1 次。实验组
患者在对照组基础上给予131I治疗。治疗结束后，检测并比较两组患者血清游离三碘甲状腺素(FT3)、游离甲状腺素(FT4)、促甲状
腺激素(TSH)、睾酮(T)、雌二醇(E2)、甲状腺球蛋白(TG)水平的变化以及临床疗效。结果：与治疗前相比，两组患者血清FT3、FT4、
T、E2、TG 水平均显著下降，TSH 水平明显升高(P<0.05)；与对照组相比，实验组患者血清FT3、FT4、T、E2、TG水平较低，TSH 水平
以及临床治疗有效率较高(P<0.05)。结论：131I 能够显著降低男性甲状腺功能亢进症血清FT3、FT4、T、E2、TG水平，升高TSH 水
平，临床效果较好。 |
| 英文摘要: |
| Objective:To investigate the effect of 131I on the serum sex hormones and thyroglobulin levels of male patients with
hyperthyroidism.Methods:74 cases of male hyperthyroidism patients treated in our hospital were selected and randomly divided into the
control group and experimental group with 37 cases in each group. Patients in control group were given oral administration of 20-30 mg/
times, 1 times per day. Patients in the experimental group were given 131I treatment based on the control group. After the end of treatment,
the detection and compared between the two groups of patients with serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid
stimulating hormone (TSH), testosterone (T) and estradiol (E2), thyroglobulin (TG) level changes and clinical curative effect in detection
and compared.Results:Compared with before treatment, the serum FT3, FT4, t, E2, TG levels of both groups were decreased after
treatment, the TSH level was significantly increased (P<0.05); compared with the control group, the serum FT3, FT4, t, E2, TG levels
were lower, the TSH level and clinical effective rate were higher (P < 0.05).Conclusion:131I could reduce the serum FT3, FT4, T, E2,
TG levels of male patients with hyperthyroidism, increased TSH level and had better clinical effect. |
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