| 高长路 沈伟东 吴迪 李萌 杨冬冬 孙凌宇 张岂凡.Nell-1基因启动子区甲基化在胃癌中的研究*[J].,2016,16(22):4274-4279 |
| Nell-1基因启动子区甲基化在胃癌中的研究* |
| Research on Nell-1 Promoter Methylation Patterns in Patients with GastricCancer |
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| DOI： |
| 中文关键词: 甲基化率 胃癌 基因 |
| 英文关键词: Methylation rate Gastric cancer gene |
| 基金项目:黑龙江省教育厅科学技术研究面上项目（12541537） |
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| 中文摘要: |
| 目的：探讨Nell-1基因启动子区不同甲基化位点与胃癌患者术后病理分期及淋巴结转移度之间相关性。方法：收集2012 年
4 月至2012 年9 月在哈尔滨医科大学附属第四临床医院肿瘤外科25 例接受胃癌根治术的病人资料，运用配对t 检验及线性回
归统计方法，分析Nell-1基因启动子区不同甲基化位点与胃癌患者临床病理资料之间的相关因素。结果：Nell-1 基因启动子区不
同甲基化位点的胃癌组织组和胃正常组织组甲基化率之间的差别有统计学意义（第1 号位点及第38 号位点），简单线性回归结
果分析显示在第1 号位点随着患者术后病理分期逐渐降低，胃癌组织组和胃正常组织组甲基化率之间的差值会逐渐增大（负相
关）；而在第38 号位点随着淋巴结转移度的逐渐增大，胃癌组织组和胃正常组织组甲基化率之间的差值会逐渐增大（正相关）。结
论：胃癌的发生受诸多因素的影响，不同甲基化位点其甲基化率不同，其与胃癌患者临床病理资料之间存在一定相关性。 |
| 英文摘要: |
| Objective:To investigate the relationship between promoter methylation patterns and pathological data of
gastric cancer patients.Methods:The clinical data of 25 cases of gastric cancer surgery performed from April to September 2012 in
Department of Surgical Oncology, The Fourth Hospital of Harbin Medical University was included into the study. Using paired t test and
linear regression analysis, the correlation factors of Nell-1 gene promoter methylation patterns and clinical pathological data of gastric
cancer patients were analyzed.Results:The difference of methylation rates between gastric cancer tissues and normal gastric tissues in
different methylation sites of gene promoter region was statistically significant (1 and 38). Results of simple linear regression
analysis showed that the difference of methylation rates between gastric cancer tissues and normal gastric tissues was gradually increased
when the pathological stage of the patients gradually decreased(Negative Correlation) in the first site. The difference of methylation rates
between gastric cancer tissues and normal gastric tissues was gradually increased when the degree of lymph node metastasis gradually
increased (Positive Correlation) in the thirty-eight site.Conclusion:The occurrence of gastric cancer is influenced by many factors, and
different methylation sites have different methylation rates. There is a correlation between the clinical pathological data of gastric cancer
patients and the difference of methylation rates in different methylation sites. |
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