| 柳培雨 田毅 王玥 杨琪琳 林晓.MicroRNA-214 在心肌缺血/再灌注的研究进展[J].,2016,16(21):4194-4196 |
| MicroRNA-214 在心肌缺血/再灌注的研究进展 |
| MicroRNA-214 in Myocardial Ischemia / Reperfusion |
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| DOI： |
| 中文关键词: microRNA-214 心肌 缺血/ 再灌注 |
| 英文关键词: MicroRNA-214 Myocardium Ischemia / reperfusion |
| 基金项目:海南省自然科学基金项目（814369）；海南省卫生厅科技立项（2014-10） |
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| 中文摘要: |
| MicroRNA是一种内源性的小核苷酸片段，已检测出700 余种。大约30 %的人类基因受miRNAs调节。其中miRNA-214 在
不同细胞有多种生物学作用，通过调控多种靶基因在诸多疾病中都发挥着重要作用。microRNA-214 在心肌损伤及免疫方面也发
挥积极的作用，通过抑制心肌缺血/再灌注的细胞凋亡、HIF1AN 等机制参与心肌缺血/ 再灌注，其有可能成为预防和治疗治疗心
肌缺血/ 再灌注损伤性疾病的新型靶向分子，为临床预防和治疗心肌缺血/再灌注损伤性疾病提供思路和方法。 |
| 英文摘要: |
| MicroRNA, an endogenous small nucleotide segment, has been detected more than 700 kinds. About 30 %of the human
genome is regulated by the microRNA. MicroRNA-214 plays an important role in the regulation of many types of diseases through a
variety of target genes. Accumulating evidence suggests that microRNA-214 has an active role in myocardial injury and immunity. MicroRNA-
214 attends the procedure of myocardial ischemia / reperfusion by inhibition of cell apoptosis, HIF1AN mechanism. It may become
a new novel targeted marker in the prevention and treatment of myocardial ischemia / reperfusion injury, and microRNA-214 will
provide ideas and methods for myocardial ischemia / reperfusion injury disease. |
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