| 李稳 马欣 汪静△ 王竹 陈玉娟.长链非编码RNA 在乳腺癌中的研究进展[J].,2016,16(21):4174-4176 |
| 长链非编码RNA 在乳腺癌中的研究进展 |
| Progress on the Relationship between Breast Cancer and Long Non-codingRNA |
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| DOI： |
| 中文关键词: 长链非编码RNA 乳腺癌 研究进展 |
| 英文关键词: Long non-coding RNA Breast cancer Progression of study |
| 基金项目:四川省科技厅科技支撑项目（0040205301C24）；吴阶平医学基金项目(312130022) |
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| 中文摘要: |
| 乳腺癌是女性最常见的恶性肿瘤之一，且其发病率呈逐年上升的趋势，尽管随着诊疗技术的进步，乳腺癌的死亡率得到了
实质性的降低，但它仍是女性肿瘤死亡的第二大原因，目前对乳腺癌的治疗还面临很大的挑战。长链非编码RNA(Long non-coding
RNA, LncRNA)是一类长度超过200 个核苷酸的非编码RNA 分子，缺乏开放的阅读框，无编码蛋白质的功能。近年来研究发现，
LncRNA 可能在多种恶性肿瘤的发生、发展、侵袭及转移过程中起调控作用，且目前对其与乳腺癌的关系研究较多，对LncRNA
与乳腺癌相关性的研究有望为乳腺癌的诊治提供新思路。现就LncRNA 在乳腺癌中的研究进展做一综述。 |
| 英文摘要: |
| Breast cancer is one of the most common cancer in women and its incidence continues to rise. Despite the improvements
of diagnose and treatment, breast cancer remains the second most common cause of death fromcancer in women and there is still a
big challenge for its treatment. Long non-coding RNAs (LncRNAs) are a type of transcripts longer than 200 nucleotides and without protein-
coding capacity. Recently, many studies have shown that LncRNA play an important role in tumorigenesis, invasion and metastasis
and it may provide a new method for the diagnosis and treatment of breast cancer. This review was focused on the progress on the relationship
between LncRNAand breast cancer. |
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