| 邹远康 李天 温博 李国印 贾林涛 王磊.蛋白激酶AKT 不同亚型影响乳腺癌恶性表型的研究进展[J].,2016,16(21):4165-4169 |
| 蛋白激酶AKT 不同亚型影响乳腺癌恶性表型的研究进展 |
| Advances in Understanding the Specific Roles Played by Different AKTIsoforms in Affecting Malignant Phenotypes of Breast Cancer |
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| DOI： |
| 中文关键词: AKT 不同亚型 乳腺癌 增殖 转移 |
| 英文关键词: AKT isoforms Cancer Proliferation Metastasis |
| 基金项目:国家自然科学基金项目（81472631）；第四军医大学"青年英才支持计划" 资助项目（2015） |
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| 中文摘要: |
| 细胞的增殖、转移、存活等细胞生物学过程的异常对人类众多疾病尤其是恶性肿瘤的发生发展至关重要。大量研究表明，
PI3K/AKT 信号通路的异常激活在肿瘤的恶性转化过程中发挥重要作用并具有普遍意义。但是，目前的研究多集中于探讨AKT
总的激酶活性，而往往忽视了AKT 不同亚型的特异性功能。近年来在乳腺癌中的研究发现，AKT 家族不同亚型的激酶分子在调
控肿瘤细胞的存活、生长、增殖、代谢、转移等众多恶性表型方面发挥独特而关键的作用：与Akt1 促进肿瘤细胞增殖、抑制肿瘤细
胞转移的作用相反，Akt2 在促进肿瘤细胞转移、抑制肿瘤细胞增殖方面发挥重要功能；此外，随着对AKT 家族研究的深入，人们
对Akt3 的特异性生物学功能也有了新的认识。本文在此对AKT 不同亚型与乳腺癌恶性表型之间关系的研究进展做一总结。 |
| 英文摘要: |
| The abnormality of cell proliferation, migration and survival is pivotal in the pathogenesis of several human diseases
especially cancer. Abnormal activation of PI3K/AKT pathway plays an essential role in the process of malignant transformation and has
universal significance. Among numerous studies, the effect of PI3K/AKTdysregulation on themalignant phenotypes of breast cancer attracts
more attention. Different isoforms of AKT play specific roles in regulating multiple malignant phenotypes such as cancer cell survival,
growth, proliferation, metabolism, metastasis and so on. Overexpression of Akt1 usually promotes cancer cell proliferation and inhibits
tumor metastasis. However, contrary to the functions of Akt1, overexpression of Akt2 often leads to enhanced tumor metastasis and suppressed
cell proliferation. More recently, with the studies of AKT families going deeper, we now have a new understanding of the specific
role of Akt3. Here, the relationships between different AKT isoforms and specific malignant phenotypes of breast cancer are summarized
and reviewed. |
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