| 赵军 李强 杨世峰 孙玲 宁婷.甲状旁腺激素水平对慢性肾衰竭患者维持性血液透析期间机体营养的影响[J].,2016,16(21):4150-4152 |
| 甲状旁腺激素水平对慢性肾衰竭患者维持性血液透析期间机体营养的影响 |
| Effect of Parathyroid Hormone on Nutrition of Patients with Chronic Renal Failure during Maintenance Hemodialysis |
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| DOI： |
| 中文关键词: 慢性肾衰竭 维持性血液透析 甲状旁腺激素 营养不良 |
| 英文关键词: Chronic renal failure Maintenance hemodialysis PTH Malnutrition |
| 基金项目:陕西省科技攻关项目(2012K13-02) |
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| 中文摘要: |
| 目的：探讨慢性肾衰竭（CRF）维持性血液透析患者血清甲状旁腺激素（PTH）水平与机体营养状况的关系。方法：选择2013
年8 月-2015年10 月我院收治的慢性肾衰竭行维持性血液透析治疗的患者98 例作为研究组，另选择同期接受健康体检的志愿
者69 例作为对照组。采用放射免疫法检测两组患者血清甲状旁腺激素（PTH）及血清学指标。采用微型营养评定法（MNA）评价两
组患者营养状况；利用Spearman 相关分析方法评价血清PTH与相关血清生化指标的相关性。结果：研究组营养不良发生率
（31.63%）明显高于对照组（13.04%），差异具有统计学意义（P<0.05）。研究组营养不良患者血清PTH，HDL-C，LDL-C，CRP，BUN
及SCr 水平均高于潜在营养不良和营养正常者，而血清TP，ALB，TC，TG 及Hb均低于潜在营养不良和营养正常者（P<0.05）。潜
在营养不良患者血清PTH，HDL-C，LDL-C，CRP，BUN及SCr 水平均高于营养正常者，而血清TP，ALB，TC，TG 及Hb 均低于营
养正常者（P<0.05）。慢性肾衰竭患者血清PTH与MNA，TP，TC，TG，CRP以及Hb呈负相关关系（P<0.05）；与BUN，SCr 呈正相关
关系（P<0.05）；与ALB，HDL-C，LDL-C 无明显相关性（P>0.05）。结论：CRF患者并发营养不良的发生率较高，血清PTH 水平与机
体营养状况存在一定相关性，临床应予以重视。 |
| 英文摘要: |
| Objective:To investigate the relationship between serumparathyroid hormone (PTH) level and nutritional status in patients
with chronic renal failure (CRF) who had taken the maintenance hemodialysis therapy.Methods:98 cases with chronic renal failure
who were treated with maintenance hemodialysis in our hospital fromAugust 2013 to October 2015 were selected as the study group, and
another 69 healthy volunteers were chosen to be the control group. Then the levels of PTH, HDL-C, LDL-C, CRP, BUN, SCr, TP, ALB,
TC, TG and Hb in the serum of patients were detected by radioimmunoassay. The nutritional status of the two groups was evaluated by
mini nutritional assessment (MNA), and the correlation between serumPTH and serumbiochemical parameters was evaluated by Spearman
correlation analysis.Results:The incidence of malnutrition in the study group was 31.63%, which was higher than 13.04% in the
control group (P<0.05); The levels of PTH, HDL-C, LDL-C, CRP, BUN and SCr in the serum of CRF patients with malnutrition were
higher than those of the patients with latent malnutrition and balanced nutrition, and the levels of TP, ALB, TC, TG and Hb were lower
(P<0.05); The levels of PTH, HDL-C, LDL-C, CRP, BUN and SCr in the serumof CRF patients with latent malnutrition were higher than
those of the patients with balanced nutrition, and the levels of TP, ALB, TC, TG and Hb were lower (P<0.05); There was positive relationship
between PTH and BUN and SCr (P<0.05); There was negative relationship between PTH and MNA, TP, TC, TG, CRP and Hb
(P<0.05); There was no correlation between PTH and ALB, HDL-C and LDL-C (P>0.05).Conclusion:High levels of PTH in the serum
CRF patients was the risk factor of malnutrition, which should pay more attention in the clinical field. |
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