| Objective:To explore the correlation of gastrointestinal motility disorder and gastrointestinal hormone in patients with
acute pancreatitis (AP).Methods:A total of 90 patients with AP, who were admitted to Affiliated Hospital of Yan'an University from
March 2014 to April 2015, were chosen as case group, which was divided into mild acute pancreatitis group (MAP group, 39 patients),
moderately severe acute pancreatitis group (MSAP group, 33 patients) and severe acute pancreatitis group (SAP group, 18 patients) according
to the severity of the disease; and 30 healthy people who were accepted physical examination over the same period were selected
as control group. The levels of serum motilin(MTL), vasoactive intestinal peptide(VIP) 1 day, 3days, and 7 days after admission in each
group were measured by the double antibody sandwich enzyme-linked immunosorbent assay (ELISA) method; meanwhile, The severity
of AP was judged with the oro-cecal transit time(OCTT).Results:The levels of serumMTL in MAP group, MSAP group and SAP group
were significantly lower than those in control group, which were gradually increased along with the extended of the admission time,the
differences were statistically significant(P<0.05). The levels of serumVIP in MAP group, MSAP group and SAP group were significantly
higher than those in control group, which were gradually reduced along with the extended of the admission time, the differences were statistically
significant (P<0.05). The level of serum MTL was negatively correlated with OCTT (rs=-0.534, -0.629, -0.468, P<0.05); while
the level of serumVIP was positively correlated with OCTT(rs=0.464, 0.326, 0.671, P<0.05).Conclusion:Gastrointestinal motility disorder
may be correlated with abnormal gastrointestinal hormone, performed as the reduced level of MTL and increased level of VIP, its
change extent is consistent with the severity of the disease. |
