| 田怡 欧阳松 王家祺 柳四新 余孝君 朱宏.Hcy, hs-CRP与急性脑梗死患者颈动脉粥样硬化关系的研究[J].,2016,16(20):3853-3855 |
| Hcy, hs-CRP与急性脑梗死患者颈动脉粥样硬化关系的研究 |
| Research on the Correlation of Hcy, hs-CRP and Carotid ArteryAtherosclerosis in Patients with Acute Cerebral Infarction |
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| DOI： |
| 中文关键词: Hcy hs-CRP 急性脑梗死 颈动脉粥样硬化 |
| 英文关键词: Hcy hs-CRP Acute cerebral infarction Atherosclerosis |
| 基金项目:国家自然科学基金青年基金项目（81202730） |
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| 中文摘要: |
| 目的：探讨急性脑梗死患者血清同型半胱氨酸(Hcy)、超敏C 反应蛋白(hs-CRP)与颈动脉粥样硬化的相关性及临床意义。方
法：收集确诊为急性脑梗死患者90 例，对患者进行颈动脉超声检查，根据颈动脉狭窄程度将患者分成颈动脉内膜正常组、轻度狭
窄组、中-重度狭窄组。比较三组患者斑块检出率、Hcy、hs-CRP 水平和IMT 厚度，同时对Hcy、hs-CRP 与IMT 进行相关性分析。
结果：中- 重度狭窄组斑块检出率为86.4%，显著高于轻度狭窄组和颈动脉内膜正常组(p<0.05)；颈动脉内膜正常组Hcy、hs-CRP
水平以及IMT 厚度均显著低于颈动脉轻度狭窄组、中-重度狭窄组(p<0.05)；hs-CRP与IMT 呈正相关(r=0.71，P<0.05)；Hcy与
IMT 呈正相关(r=0.79，P<0.05)。结论：血清Hcy 和hs-CRP 水平与颈动脉粥样硬化程度密切相关，Hcy、hs-CRP联合检测对急性脑
梗死的早期诊断和预后有着重要临床意义。 |
| 英文摘要: |
| Objective:To explore the correlation between serum homocysteine (Hcy), high sensitive C-reactive protein (hs-CRP)
and carotid artery atherosclerosis in acute cerebral infarction patients.Methods:90 cases with acute cerebral infarction were examined by
color Doppler ultrasonography to detect carotid artery stenosis. Based on the severity of stenosis of common carotid artery (CCA), all
patients were divided into three groups including the normal group (n=26), the slight stenosis group (n=42), the moderate-severe stenosis
group (n=22). The experimental results of detected rates of the plaques, Hcy, hs-CRP, IMT were compared between the three groups and
the correlation analysis was performed.Results:Detected rates of plaques in the moderate-severe stenosis group was 86.4%, which was
statistically higher than that of the slight stenosis group and normal group. The serum Hcy and hs-CRP level of the normal group was
statistically lower than that of the slight stenosis group and moderate-severe stenosis group (P<0.05). The Hcy level was positively
correlated with IMT (r=0.71, P<0.05) and the hs-CRP level was also positively correlated with IMT (r=0.79, P<0.05).Conclusion:The
serum Hcy and hs-CRP levels are closely correlated with the severity of the stenosis of CCA. Detection of Hcy combined with hs-CRP
level is of great significance to the early diagnosis and prognosis of acute cerebral infarction patients. |
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