| 孙丽丽 李慧波 范圣瑾 孔德胜 李英花△.microRNA及Wnt 信号通路在急性淋巴细胞白血病中的作用研究进展[J].,2016,16(19):3779-3782 |
| microRNA及Wnt 信号通路在急性淋巴细胞白血病中的作用研究进展 |
| Research Progress on the Relationship between microRNA/Wnt SignalingPathway and Acute Lymphoblastic Leukemia |
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| DOI： |
| 中文关键词: microRNAs 急性淋巴细胞白血病 Wnt信号通路 DKK3 |
| 英文关键词: microRNAs Acute lymphoblastic leukemia Wnt signaling pathway DKK3 |
| 基金项目:教育部博士点博导类基金项目（20132307110022） |
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| 中文摘要: |
| microRNAs(miRNAs)是一种内源性的基因调控元件，参与细胞增殖、分化、凋亡等多种重要生物学过程。在许多实体瘤和血
液系统恶性肿瘤中均存在miRNA 异常表达，说明miRNA可能参与肿瘤的发生及发展。Wnt 通路是一条经典的信号通路，其异常
激活与多种实体瘤和血液系统恶性肿瘤的发生发展密切相关。急性淋巴细胞白血病（acute lymphoblastic leukemia, ALL)是一种常
见的成人血液系统恶性肿瘤，现已发现多种miRNA在ALL中异常表达，并与发病、治疗效果及预后有关。在ALL中可见Wnt信
号通路的异常激活及通路抑制剂的异常失活，并且这些变化与ALL的预后密切相关。本文就miRNAs 和Wnt 信号通路在急性淋
巴细胞白血病（acute lymphoblastic leukemia, ALL）中的作用相关研究进展作一综述，以提供靶向治疗ALL的新思路。 |
| 英文摘要: |
| The microRNAs (miRNAs) is a type of endogenous gene regulatory element, which involving in many key biological
processes, such as cell proliferation, differentiation and apoptosis. Dysregulation of miRNA in many solid tumor and hematologic tumor
could suggest that miRNA may involve in the development and process of tumor. Wnt signaling pathway is a classic pathway, of which
abnormal activation is closely related to many solid tumor and hematologic malignancies. Acute lymphoblastic leukemia (ALL) is a common
type of adult hematologic malignancies, many miRNAs dysregulation are found in ALL, and closely related to progression, treatment
effect and prognosis of ALL. Aberrant activation of Wnt signaling pathway and inactivation of Wnt inhibitor were found in ALL,
and were related to prognosis of ALL. Currently, we review on the roles of miRNAs and Wnt signaling pathway on acute lymphoblastic
leukemia, and provide a new strategy to target treatment ALL. |
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