| 宋亦飞 朱丹 丛林 聂雪丹 丁思文 梁庆成.影响尿激酶静脉溶栓治疗急性脑梗死预后因素的初步分析[J].,2016,16(19):3687-3691 |
| 影响尿激酶静脉溶栓治疗急性脑梗死预后因素的初步分析 |
| Pilot Study of Factors Influencing Outcoming of Acute Ischemic StrokeTreated with Urokinase |
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| DOI： |
| 中文关键词: 尿激酶 急性缺血性脑卒中 预后 |
| 英文关键词: Urokinase Acute ischemic stroke Prognosis |
| 基金项目:国家" 十二五" 科技支持计划课题（2011BAI08B11） |
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| 中文摘要: |
| 目的：对影响急性缺血性脑卒中患者应用尿激酶溶栓治疗预后的相关危险因素进行初步分析及研究，为今后选择适宜应用
尿激酶溶栓的患者打下基础。方法：以2015 年1 月1 日至2015 年10 月31 日入院且应用尿激酶静脉溶栓的38例急性缺血性脑
卒中患者, 根据治疗3 个月后的预后情况将患者分为A组(24 例,预后良好) 和B 组(14 例, 预后不良)，对两组患者的预后影响因
素进行分析。结果：预后良好组患者的溶栓前NIHSS评分低于预后不良组，差异具有统计学意义（P＜0.05）。多因素的Logistic 回
归分析显示，吸烟和HINSS 评分与急性脑梗死尿激酶溶栓预后不良有关，差异具有统计学意义（P＜0.05），且NIHSS 评分是预后
的独立预测因素。结论：尿激酶静脉溶栓治疗脑梗死的患者，溶栓前较高的NIHSS评分可能与溶栓预后不良有关。吸烟的患者溶
栓后出现预后不良的几率是不吸烟患者溶栓后预后不良的8.83 倍，溶栓前NIHSS 评分每增加1 分，溶栓预后不良的几率增加
1.76 倍。 |
| 英文摘要: |
| Objective:Pilot study and analysis of prognosis and risks regarding urokinase for acute ischemic stroke. This study will
form foundation for candidate selection for the use of urokinase.Methods:38 cases of acute ischemic stroke admission treated with intravenous
urokinase from1/1/2015 to 31/10/2015 are divided intoA (24 participants, favorable outcome) and B group (unfavourable outcome)
based on prognosis after three months. Factors associated with different outcomes are discussed in this study.Results:NIHSS
score from favorable outcome group was lower than unfavourable outcome group (with statistical significance, P<0.05). NIHSS scoreis
the independent predictors of prognosis.Conclusion:Conclusion: in acute ischemic stroke patient treated with intravenous urokinase,
higher NIHSS score may be associated with poorer outcome. Patients who smoke are 8.83 times more likely to encounter poor outcome.
With every point increase of NIHSS score prior to thrombolysis, the odds of unfavorable outcome was increased by 1.76 times. |
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