| 丁兰 赵超 安静 王宇虹 韩辉△.血浆游离DNA在临床应用中的新进展[J].,2016,16(18):3593-3596 |
| 血浆游离DNA在临床应用中的新进展 |
| New Progress in Plasma Cell-free DNA in Clinical Applications |
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| DOI： |
| 中文关键词: 血浆游离DNA 分子标记物 肿瘤诊断 产前诊断 |
| 英文关键词: Plasma cell-free DNA Molecular markers Cancer diagnosis Prenatal diagnosis |
| 基金项目:卫生部行业科研基金项目（20100201） |
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| 摘要点击次数: 710 |
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| 中文摘要: |
| 血浆游离DNA（Plasma cell-free DNA,cf-DNA）是存在于人体血液中一种无细胞状态的胞外DNA。作为细胞死亡的标记物，
近年来cf-DNA 检测已用于多种急性或慢性疾病的诊断和预后评价中。虽然在健康人群的血浆中也可测量到一定量的cf-DNA，
但据相关报道称在癌症，自身免疫性疾病，中风，败血症，先兆子痫和器官移植排斥中cf-DNA 呈显著的高水平。本文对cf-DNA
在临床工作中应用的新进展做出综述，观察其在肿瘤诊断，产前诊断，脓毒症及老年免疫衰老评估作用中的新进展，发现其相较
其他生物标记物敏感性并无太大差别，但特异性更高，还可能与肿瘤的转移机制相关。对于老年个体衰老的机制尚未明确，炎症
学说也尚未得到证实，如何评定衰老以及明确衰老的标记物已成为全世界研究的难点，而cf-DNA浓度可能代表了一种全身炎症
反应和老年人死亡率新的生物标志物。这些研究都使得cf-DNA应用于临床工作中的前途更加光明。 |
| 英文摘要: |
| Plasma cell-free DNA (cf-DNA) is a cell-free DNA which existing in the in the extracellular blood. As a marker of
cell death, cf-DNA has been used to detect and diagnose a variety of acute or chronic diseases and to evaluated their prognosis In recent
years. Although a certain amount cf-DNA in the plasma of healthy people could be detected, the high level of cf-DNA have been reported
in cancer, autoimmune disease, stroke, sepsis, preeclampsia, and organ transplant rejection. This article aims at the progress of cf-DNA in
the clinical. It have been found that the specificity of the cf-DNA could be higher than other biomarkers on the basis of the new advances
on the diagnosis of cancer, prenatal, sepsis and immune senescence assess for elderly people, as well as the mechanism of tumor
metastasis. It has been unclear on the mechanism for older individuals, the inflammation hypothesis. The difficulty is the way to assess a
clear marker of aging people. However, cf-DNA concentrations may represent a systemic inflammatory response and death in the elderly
the rate of new biomarkers. These studies have made cf-DNA in clinical work even brighter future. |
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