| 常久魁 刘晓荣 郑建辉 周晋 刘维田 徐雅彪 张国栋 孟根托娅 刘超.NT-proBNP 与H-FABP在高血压性脑出血患者近期预后的相关性分析[J].,2016,16(16):3154-3157 |
| NT-proBNP 与H-FABP在高血压性脑出血患者近期预后的相关性分析 |
| Correlation Analysis of SerumNT-proBNP and Heart-fatty Acid BindingProtein and SerumHomocysteine in Recent Prognosis of Patients withHypertensive Cerebral Hemorrhage |
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| DOI： |
| 中文关键词: N 末端B 型钠尿肽原 心脏型脂肪酸结合蛋白 脑血压脑出血 |
| 英文关键词: N end of b-type natriuretic peptide The heart type fatty acid binding protein Cerebral hemorrhage blood pressure |
| 基金项目:河北省教育厅科学技术研究项目（2011896）；中国博士后面上基金项目（2015M572272） |
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| 中文摘要: |
| 目的：探讨血清N 末端B 型钠尿肽原(NT-proBNP)与心脏型脂肪酸结合蛋白(H-FABP)与高血压性脑出血患者近期预后的相
关性分析。方法：选取我院收治的160 例高血压脑出血患者为研究对象，检测患者入院第1 d、3 d、7 d的血清NT-proBNP、H-FABP
水平，按照入院后3 个月的改良Rankin 量表(mRS)评分对患者的预后进行评估，分为预后良好组(mRS 评分≤ 2 分)及预后不良组
(mRS 评分＞2 分)；比较两组相关指标的差异。用Logistic回归方程分析血清NT-proBNP、H-FABP 与mRS评分的关系。结果：与
预后良好组比较，预后不良组患者入院后3 个月的mRS 评分较高，而入院格拉斯哥昏迷量表评分(GCS)评分较低(P＜0.05)；预后
不良组患者入院第3 d、7 d的血清NT-proBNP、H-FABP 高于预后良好组(P＜0.05)；Spearman 相关性分析提示入院第1 d、3 d、7 d
的血清NT-proBNP、H-FABP 分别与mRS 评分呈正相关，而与GCS 呈负相关(P＜0.05)；多因素Logistic 回归分析显示：入院第
3d、7d 的血清NT-proBNP、H-FABP是高血压脑出血患者预后不良的独立危险因素(P＜0.05)。结论：血清NT-proBNP、H-FABP 与
高血压脑出血患者的近期预后具有一定的相关性，可能是患者近期预后不良的独立危险因素。 |
| 英文摘要: |
| Objective:To investigate the serumlevels ofN terminal B type natriuretic peptide (NT-proBNP) with heart type fatty
acid binding protein (H-FABP) and correlation analysis of recent prognosis of patients with hypertensive cerebral hemorrhage.Methods:160 cases of hypertension cerebral hemorrhage patients in our hospital were selected as the research objects. All patients had their serum
levels of NT-proBNP and H-FABP detected on 1 d, 3 d, 7 d on admission. According to the modified Rankin scale (mRS) scores at 3
months after admission, patients were divided into good prognosis group (mRS score ≤ 2) and poor prognosis group (mRS score > 2).
Compare the difference of related indicators between the two groups, and investigate the relationship of serum NT-proBNP and H-FABP
levels with mRS score by Logistic regression equation analysis.Results:Compared with good prognosis group, the mRS score of patients
admitted to hospital after 3 months was high, but the Glasgow coma scale (GCS) score was low in poor prognosis group (P < 0.05); The
serum NT-proBNP and H-FABP levels at 3 d, 7 d on admission was higher in poor prognosis group than in good prognosis group (P<0.
05). Spearman correlation analysis results showed that in hospital 1 d, 3 d, 7 d serum NT-proBNP and H - FABP levels were positively
correlated with the mRS scores, but negatively correlated with GCS, respectively (P<0.05). Multiariable logistic regression analysis
showed that in hospital 3 d, 7 d serum NT-proBNP and H-FABP levels were independent risk factors for poor prognosis of hypertension
cerebral hemorrhage patients (P<0.05).Conclusion:The serum NT-proBNP and H-FABP levels had certain relevance with the recent
prognosis of patients with hypertension cerebral hemorrhage. They may be independent risk factors for recent poor prognosis of patients
with hypertension cerebral hemorrhage. |
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