| 叶丹 黄文博 李小波 关文达 伍时冠 杨子峰 黄吉城.二氧化氯溶液消毒剂对呼吸道病毒的杀灭效果评估[J].,2016,16(16):3105-3107 |
| 二氧化氯溶液消毒剂对呼吸道病毒的杀灭效果评估 |
| Effect Evaluation of Chlorine Dioxide Solution Disinfectant on KillingRespiratory Tract Viruses |
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| DOI： |
| 中文关键词: 二氧化氯 消毒剂 呼吸道 病毒 感染 |
| 英文关键词: Chlorine dioxide Disinfectant Respiratory tract Virus Infection |
| 基金项目:2014 年度广东省医学科研基金项目（A2014295）；广东省省级科技计划(2013B020224006)；
广州市科技计划项目-科技惠民专项（2014Y2-00031） |
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| 中文摘要: |
| 目的：评估" 菌bye-bye" 消毒剂对甲型H1N1 流感病毒PR8（PR8）、呼吸道合胞病毒（RSV）、3 型腺病毒（ADV3）、人感染
H7N9 禽流感病毒（H7N9）的体外杀灭效果。方法：参考《消毒技术规范》和受试产品说明书进行细胞毒性试验、消毒剂中和试验和
对PR8、RSV、ADV3、H7N9 病毒的体外杀灭实验。结果：（1）候选中和剂选定0.02mol/L 硫代硫酸钠（Na2S2O4）；（2）候选中和剂、"
菌-bye-bye" 消毒剂及两者混合物对细胞毒性低；（3）候选中和剂能完全中和消毒剂消毒效果；（4）随着" 菌bye-bye" 消毒剂的浓
度增大，病毒杀灭效果亦越好。在其不稀释的条件下，除了PR8 毒株外，其他3 种病毒的平均灭活率均在99.99%以上，且平均病
毒TCID50负对数值（log10 TCID50/mL）均降低4 log10或以上；对半稀释后对RSV 的杀灭效果最好，而对ADV3 的杀灭效果最差。结
论：高浓度" 菌bye-bye" 消毒剂对呼吸道病毒的杀灭效果较好，且对细胞的毒性较小，是一种安全、高效的消毒剂，值得临床推
广。 |
| 英文摘要: |
| Objective:To evaluate the effect of"Bacteria-bye-bye"disinfectant on killing H1N1 influenza virus PR8 (PR8),
respiratory syncytial virus (RSV), adenovirus 3 (ADV3), human H7N9 avian influenza (H7N9) in vitro.Methods:To performed the
cytotoxicity test, disinfectant neutralization test and PR8, RSV, ADV3, H7N9 virus killing test in vitro according to the and test product specification.Results:(1)The candidate neutralizing agent was 0.02 mol/L sodium hyposulfite
(Na2S2O4); (2)The cytotoxicity of candidate neutralizing agent, "Bacteria -bye-bye"disinfectant and their mixture were low; (3)The
candidate neutralizing agent could completely neutralize the effect of disinfectant; (4)The higher concentration of "Bacteria-bye-bye"
disinfectant, the better effect on virus killing.In the undiluted condition, except PR8, the virus inactivation rate of other 3 viruses were
above 99.99%, and the average viral TCID50 negative logarithm(log10 TCID50/mL) decreased more than 4 log10; After half to half diluted, it
had the best killing effect on RSV, but the worst killing effect on ADV3.Conclusion:High concentration "Bacteria-bye-bye" disinfectant
is effective on killing respiratory tract viruses, and has less toxic to cells,it is safe and high-performance, which is worthy of clinical
promotion. |
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