| Objective:To investigate the plasma homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP) levels in both
homozygote and heterozygote patients with familial hypercholesterolemia (FH) and the correlation with serum lipid levels.Methods:Enrolled 34 FH patients (14homozygotes, 20 heterozygote) fromour Atherosclerosis Department during 2013.10~2015.7. Three groups,
including homozygotes, heterozygotes and healthy control, were measured total cholesterol (TC), triglyceride (TG), low density
lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (Glu), Hcy, hs-CRP levels. In
addition, we investigated the correlation between LDL-C, non-high-density lipoprotein (non-HDL) levels with Hcy, hs-CRP levels in
patients with FH.Results:The level of TC, LDL-C, non-HDL and Hcy in FH group were significantly higher than the control (P <0.05).
According to genotype subgroup analysis, HDL-C level of adolescent homozygous group were lower than heterozygous group. But the
level of TC [(16.11± 2.66) vs (7.30± 2.54) mmol/L], LDL-C [(14.06± 2.22) vs (5.25± 2.16) mmol/L], non-HDL [(15.33 ± 2.60) vs
(6.05± 2.61) mmol/L] and Hcy [(19.3± 11.58) vs (11.29± 3.42) umol/L] were significantly higher than the heterozygous group (P <0.
05). Pearson correlation analysis showed that in FH group, plasma LDL-C and non-HDL levels were positively correlated with Hcy levels
(P <0.05). However, plasma LDL-C and non-HDL levels were not correlated with hs-CRP in FH paients.Conclusion:FH patients,particularly homozygous adolescents have significantly higher TC, LDL-C and Hcy levels than the control group. In addition, the level of
LDL-C, non-HDL levels in FH patients were positively correlated with Hcy levels. |
