| 徐郁 李彩霞 于晓霞 沈兰兰 包春燕.PCT, IL-6及CRP 对新生儿宫内细菌感染的诊断价值[J].,2016,16(15):2953-2955 |
| PCT, IL-6及CRP 对新生儿宫内细菌感染的诊断价值 |
| Value of PCT, IL-6 and CRP in Diagnosis of Neonatal Intrauterine Bacterial Infection |
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| DOI： |
| 中文关键词: PCT IL-6 CRP 新生儿 宫内感染 诊断 |
| 英文关键词: Procalcitonin Interleukin-6 C reactive protein Newborn Intrauterine bacterial infection Diagnosis |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨降钙素原（PCT）、白细胞介素-6（IL-6）及C 反应蛋白（CRP）对新生儿宫内细菌感染的诊断价值。方法：根据感染
结局将2013 年3 月-2014 年9 月在我院分娩且有宫内感染高危因素的179 例新生儿分为感染组（34 例）和无感染组（145 例），检
测两组新生儿的PCT、IL-6 及CRP 水平，并比较其对宫内细菌感染的诊断价值。结果：感染组新生儿脐带血PCT、IL-6、CRP 水平
均高于无感染组，差异有统计学意义（P<0.05）。感染组新生儿各单个指标阳性率、两指标联合检测阳性率高于无感染组，差异均有
统计学意义（P<0.05），感染组新生儿PCT、IL-6 阳性率高于CRP，PCT+IL-6 的阳性率高于PCT+CRP、IL-6+CRP，差异均有统计学
意义（P<0.05）。PCT+IL-6的灵敏度、准确率高于单个指标及其他两个指标联合检测，差异均有统计学意义（P<0.05），各项指标检
测的特异性比较，差异无统计学意义（P>0.05）。结论：新生儿宫内感染采用脐带血PCT 检测具有灵敏度高、特异性好的特点，联合
IL-6 检测是临床诊断新生儿宫内感染的有效方式。 |
| 英文摘要: |
| Objective:To explore the diagnosis value of procalcitonin (PCT), interleukin-6(IL-6)and C reactive protein(CRP) for
neonatal intrauterine bacterial infection.Methods:A total of 179 newborn infants with high risk factors of intrauterine infection, who
were born in 3201 hospital of China Aviation Industry from March 2013 to September 2014, were divided into infection group (34 infants)
and non-infection group (145 infants) according to the outcome. The PCT, IL-6, CRP levels of the two groups were detected and
their values were compared in the diagnosis of intrauterine bacterial infection.Results:The PCT, IL-6 and CRP levels in the umbilical
cord blood of newborn infants in the infection group were higher than those in the non-infection group, the difference was statistically
significant (P<0.05). The positive infection rates of each single index and two indicators of combination detection in the infection group
were higher than those in the non-infection group, the difference was statistically significant (P<0.05). In infection group, positive infection
rates of PCT and IL-6 were higher than that of CRP respectively; and the positive infection rate of PCT combined with IL-6 was
higher than that of PCT combined with CRP, IL-6 combined with CRP respectively, the difference was statistically significant(P<0.05).
There was no statistically significance in the sensitivity and accuracy of detection of each index(P>0.05).Conclusion:Detecting the level of
PCT in the umbilical cord blood has advantages of high sensitivity and good specificity, and combination detection of PCT plus IL-6 is
the most effective way to diagnose neonatal intrauterine bacterial infection in the clinical application. to diagnostic neonatal intrauterine
bacterial infection which was once it combined with IL-6. |
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