| 周静 李征宇 李佳琦 刘明盛 李丹.HPV+/-宫颈癌患者临床特点与预后的对比分析[J].,2016,16(15):2860-2863 |
| HPV+/-宫颈癌患者临床特点与预后的对比分析 |
| Comparison of Clinical Characteristics and Prognosis between HPV-negativeand HPV-positive Cervical Cancer |
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| DOI： |
| 中文关键词: 宫颈癌 HPV 临床特点 Kaplan-Meier生存分析 |
| 英文关键词: Cervical cancer HPV Clinical characteristics Kaplan and Meier survival analysis |
| 基金项目:国家自然科学基金项目(81170592)；四川省青年科技基金项目(2015JQ0026) |
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| 中文摘要: |
| 目的：探讨HPV 阴性与HPV 阳性宫颈癌的临床特点及其和预后的关系。方法：选取住院手术的HPV 呈阴性与阳性的宫颈
癌患者各86 例，且两组患者在年龄、FIGO 临床分期相近。分析两组患者的年龄、肿瘤临床分期、病理分型、原发肿瘤大小、分化程
度、基层浸润深度、淋巴结转移、治疗方案情况及其5年RFS 和总生存时间。结果：两组间宫颈癌患者肿瘤分化程度、肌层浸润深
度、淋巴结转移间差异有统计学意义(P<0.05)。HPV 阳性组和HPV 阴性组随访时间分别为63(13~87)个月、61(9~90)个月，5 年总
生存率分别为70.4%和61.3%，平均总生存时间分别为（73.15± 2.74）月和（62.72± 3.03）月，差异有统计学意义(p <0.05)。HPV阴
性组和HPV阳性组5 年RFS 分别为52.3%和66.4%，平均RFS 为（51.57± 4.62）月和（58.83± 3.46）月，差异有统计学意义(p <0.
05)。结论：HPV 阴性宫颈癌瘤体倾向于低分化，易发生局部侵犯和淋巴结转移，其临床预后较差。 |
| 英文摘要: |
| Objective:To research clinical characteristics and prognosis of the HPV-negative and HPV-positive cervical cancer
and the relationship between them.Methods:A retrospective analysis was conducted in this research. 86 patients with cervical cancer and
HPV negative were included in this research as HPV negative group. According to principle of 1:1 matching under the rule of age, clinical
stage FIGO, 86 patients with cervical cancer and HPV positive were included in this research as HPV positive group. Patient's age, clinical
stage, pathological classification, primary tumor size, differentiation degree, infiltration depth, lymph node metastasis and distant
metastasis at the grass-roots level were analyzed, and 5 years RFS and total survival time were compared.Results:Cervical cancer pathological
classification, clinical stage, primary tumor size, distant organ metastasis and treatment method between two groups have no statistical
difference (P> 0.05). There were statistical differences in tumor differentiation degree, muscular infiltration depth and lymph node
metastasis between two groups (P<0.05). The follow-up time of HPV-positive group and HPV-negative group was 63 (13 ~ 87) months
and 61 (9 ~ 90) months respectively. The 5-year survival rate of HPV-positive group and HPV-negative group was 70.4%and 61.3%respectively,
and the average overall survival was (73.15± 2.74) months and (62.72± 3.03) months, and the differences had statistical significance
(P<0.05). RFS of 5 years of HPV-positive group and HPV-negative group was 66.4%and 52.3%respectively, and the average
DFS was (58.83 ± 3.46) months and (51.57 ± 4.62) months, and the differences had statistical significance (P<0.05).Conclusion:HPV-negative cervical cancer tend to be poorly differentiated, local invasion and lymph node metastasis, and its clinical prognosis is
poorer than that of HPV-positive cervical cancer. |
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