| 高敏婷 钟昌明 艾娜娜 李楚文 李铭源.Rho激酶抑制剂在神经退化性疾病上的应用[J].,2016,16(14):2780-2782 |
| Rho激酶抑制剂在神经退化性疾病上的应用 |
| The Application of Rho-associated Protein Kinase (ROCK) Inhibitors inNeurodegenerative Diseases |
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| DOI： |
| 中文关键词: Rho 激酶 Rho 神经退行性疾病 Rho 激酶抑制剂 |
| 英文关键词: ROCK Rho Neurodegenerative diseases ROCK inhibitor |
| 基金项目: |
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| 中文摘要: |
| Rho 激酶，又称Rho 相关的卷曲蛋白激酶，是一类丝氨酸/苏氨酸蛋白激酶，被发现为小G蛋白Rho 的下游作用底物。由于
Rho激酶活性涉及神经细胞的功能，而且越来越多的研究表明抑制Rho 激酶的活性在数种神经退行性疾病包括帕金森病、阿尔
茨海默病、亨廷顿病、多发性硬化症,和肌萎缩性侧索硬化症等的实验模式中都有明显的效果。因此，Rho激酶已成为针对治疗神
经性退化性疾病的一个热门标靶蛋白。本文探讨Rho激酶抑制剂在神经退化性疾病上的应用及发展，使神经退行性疾病能进一
步提升治疗和在应用上的水平。 |
| 英文摘要: |
| ROCK, also called Rho associated coiled coil protein kinase, is a serine / threonine protein kinase. And it is a
downstream substrate of small G protein Rho. ROCK is known to involve in the function of neurons. More and more sudies showed that
ROCK inhibition have the dominant effects on various experimental models of neurodegenerative diseases such as Parkinson's disease
(PD), Alzheimer's disease (AD), Huntington's disease (HD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS). Thus,
ROCK becomes the potential drug target for neurodegeneration-related diseases. The application and development of ROCK inhibitors
for neurodegenerative diseases was summarized in this article with the purpose to increase the level of he therapies and application of
neurodegenerative diseases. |
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