| 王居正 孙盈 邢昊 邹鑫 刘子凡
张志培 周勇安 卢强 陈召 李小飞.非小细胞肺癌患者胸膜转移瘤中NOK的表达及其与生存期的相关性[J].,2016,16(14):2663-2666 |
| 非小细胞肺癌患者胸膜转移瘤中NOK的表达及其与生存期的相关性 |
| The Expression of NOK in NSCLC Patients with Pleural Metastasesand Its Correlation with Survival Period |
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| DOI： |
| 中文关键词: 非小细胞肺癌 胸膜转移瘤 NOK 生存期 |
| 英文关键词: NSCLC Metastatic tumor of pleura NOK Survival period |
| 基金项目:国家自然科学基金项目（81572252） |
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| 中文摘要: |
| 目的：探讨非小细胞肺癌(NSCLC)患者胸膜转移瘤中NOK 表达及其与患者生存期的相关性。方法：选取我科2014 年至
2015 年收治的Ⅳ期NSCLC 患者67 例，用软式胸腔镜取胸膜转移瘤和瘤旁胸膜，采用免疫组化法测定NOK的表达情况，分析胸
膜转移瘤和瘤旁胸膜中NOK 的表达的无差异性；对患者进行随访，并分析胸膜转移瘤和瘤旁胸膜中NOK 的表达与患者生存期
的相关性。结果：①Ⅳ期NSCLC 患者胸膜转移瘤中NOK 的表达明显高于瘤旁胸膜，具有统计学差异(P<0.05)；②Ⅳ期NSCLC 患
者胸膜转移瘤中NOK 的表达量与患者的生存期呈负相关，瘤旁胸膜中NOK 的表达量与患者的生存期无显著相关性。结论：
NSCLC 患者胸膜转移瘤中NOK 的表达异常上调，且与患者的生存期呈负相关，可做为判断Ⅳ期NSCLC患者生存期的参考指
标。 |
| 英文摘要: |
| Objective:To investigate the NOK expression in NSCLC patients and its correlation with the prognosis.Methods:67
cases of NSCLC patients at stage Ⅳ with pleural metastases who admitted in our division from 2014 to 2015 were selected, and
metastatic tumor of pleura and pleura beside the tumor were obtained using soft thoracoscopic, then the expression of NOK in the two
kinds of issues were detected by immunohistochemistry, then the correlation of NOK expression in metastatic tumor of pleura and pleura
beside the tumor with the prognosis of patients were analyzed.Results:① The expression of NOK in metastatic tumor of pleura was
apparently higher than that frompleura beside the tumor (P<0.05); ②The expression of NOK in metastatic tumor of pleura was inversely
related to the survival period of patients (P<0.05), while there was no significant relationship between the expression of NOK in pleura
beside the tumor and survival of patients.Conclusion:The expression of NOK in metastatic tumor of pleura was inversely related to the
survival period of NSCLC patients at stage Ⅳ, which could be used as the standard for assessing the survival of NSCLC patients at stage
Ⅳ. |
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