| 黄智莉 于天启 陈志雄 陈亚勇 郭珊珊.巨噬细胞移动抑制因子在多发性骨髓瘤中表达意义[J].,2016,16(14):2628-2630 |
| 巨噬细胞移动抑制因子在多发性骨髓瘤中表达意义 |
| Expression and Significance of Macrophage Migration Inhibitory Factor inMultiple Myeloma |
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| DOI： |
| 中文关键词: 多发性骨髓瘤 巨噬细胞移动抑制因子 肿瘤负荷性指标 |
| 英文关键词: Multiple myeloma Macrophage migration Inhibitory Factor Tumor load indexes |
| 基金项目:广东省中医药管理局课题（20141209） |
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| 中文摘要: |
| 目的：观察巨噬细胞移动抑制因子（Macrophage migration Inhibitory Factor，MIF)在多发性骨髓瘤(Multiple Myeloma ，MM）患
者血浆中的表达及与肿瘤负荷指标包括血茁2－微球蛋白（serum 茁2 microglobulin，茁2-MG）、C－反应蛋白（C- reactive protein，
CRP）、乳酸脱氢酶（lactic acid dehydrogenase，LDH）、血清白蛋白（serumalbumin，ALB）的相关性。方法：随机选择多发性骨髓瘤患
者30 例作为观察组，28 例健康人为对照组。以ELISA（enzyme－linked immunosorbent assay，ELISA）方法检测两组人群静脉血浆
MIF浓度，并检测观察组肿瘤负荷相关指标，分析与MIF相关性。结果：①与对照组MIF检测浓度值比较（2386.76± 679.66
pg/mL），观察组血浆MIF浓度明显高表达（8153.18.16± 2043.73 pg/ml），两组比较，具有统计学意义，P<0.05。②MIF与beta2－MG、
CRP呈正相关（p=0.031、0.021；r=0.712、0.46）；与ALB 呈负相关（p=0.047；-0.215）；与LDH无明显相关性（P=0.679）。结论：MIF检
测在多发性骨髓瘤的临床诊断、分期和判断预后有重要参考价值。 |
| 英文摘要: |
| Objective:To observe the correlation of the expression of Macrophage migration inhibitory factor in Multiple
myeloma patient's plasma and the tumor load indexes including serum beta2 microglobulin（beta2-MG）, C-reactive Protein（CRP）, lactate
dehydrogenase（LDH）and serum albumin（ALB）.Methods:30 MM patients were chosen randomly as observation group, 28 healthy
people were chosen as control group. The expression of MIF level was measured by enzyme－linked immunosorbent assay（ELISA）in
each group, and the indexes of tumor load were detected in observation group. At last，we researched on the association of MIF with
tumor load indexes.Results:① compared with the detected concentration(2386.76± 679.66 pg/mL）of the control group, the serum MIF
concentration of observation group had high expression significantly (8153.18.16 ± 2043.73 pg/mL）, the difference was statistically
significant(P<0.05）.②there was apositive correlation(p=0.031, 0.021; r=0.712, 0.46）between levels of MIF and 茁2-MG, CRP. there was
a negative correlation between level of ALB (p=0.047; -0.215）, and there was no obvious correlation (P=0.679）with level of LDH.Conclusion:MIF detection had important value on MM's clinical diagnosis, clinical stage, and judging prognosis. |
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